代谢综合征患者生活方式干预的临床研究  

A study on effects of life style intervention on subjects with metabolic syndrome

作　　者：王绪山[1] 徐祥英[1] 倪子琴 朱一娥 骆秉铨 

机构地区：[1]江苏省灌云县人民医院,222200 [2]徐州市心血管病研究所

出　　处：《中国康复医学杂志》2007年第9期805-808,共4页Chinese Journal of Rehabilitation Medicine

基　　金：江苏省连云港市卫生局科研课题计划(2005038)

摘　　要：目的:评价代谢综合征患者强化生活方式干预的临床效果及其作用机制。方法:从体检对象中筛查出代谢综合征患者96例,随机分为两组,生活方式干预(体育锻炼、控制饮食、停止吸烟等)组48例,对照(健康宣教)组48例。测定基线和强化生活方式干预1年后代谢综合征相关的测量参数、生化指标和血清脂联素水平。结果:干预组,强化干预1年后,体重减少9%,代谢综合征相关危险因素,包括肥胖、高血压、高血糖、高甘油三酯,低高密度脂蛋白均有明显改善(P<0.01或P<0.05)。血清脂联素增加(P<0.01),且脂联素与腰围、血糖、舒张压、甘油三酯之间呈负相关(r=-0.399,-0.409,-0.286,-0.297,P<0.01或P<0.05),而与高密度脂蛋白呈正相关(r=0.396,P<0.01)。结论:经过强化生活方式干预1年后,能够获得减轻体重、改善代谢综合征相关危险因素和增加心血管保护因子。脂联素可以作为心血管疾病的一种保护性标志物。Objective： To assess the effects of intensive life style intervention on subjects with metabolic syndrome（MS）. Method： A total of 96 subjects with MS were screened from healthy physical examine participants, and were randomly divided into intervention（physical traning ,diet control, smoking cessation, et al.）group（n=48）, and control （healthy education ） group （n =48）. MS-relative indexes of measurement and biochemistry as well as adiponectin in serum were detected. Result： In intervention group, after one year of lifestyle modification, the mean loss of body weight was 9% of initial weight. MS-relative risk factors including increased waist circumference, high blood pressure, high fasting glucose triglyceride, and low HDL were all improved （P〈0.01 or P〈0.05）. The adiponectin level raised comparing with the basal state （P〈0.01）, and the adiponectin was inversely related with WC,FBG, DBP,TG（r=-0.399,-0.409,-0.286,-0.297,P〈0.01 or P〈0.05 respectively）, but positively with HDL（r=-0.396,P〈 0.01）. In control group after follow-up for one year, indexes of MS-relative risk factors had no significantly difference（P〉0.05）. Conclusion： The beneficial effects of intensive life style intervention are lossing body weight and improving metabolic risk factors as well as enhancing protective factors. The adiponectin may be as protective factor of cardiovascular disease.

关 键 词：代谢综合征 体重 体育锻炼 脂联素 

分 类 号：R589[医药卫生—内分泌]