乙型肝炎病毒慢性感染的临床免疫学检测和研究的重要性  

Importance of reserach and assay of clinical immunology for patients with chronic hepatitis B

作　　者：王福生[1] 陈威巍[1] 

机构地区：[1]解放军第三○二医院传染病研究所,北京100039

出　　处：《中华检验医学杂志》2007年第10期1085-1089,共5页Chinese Journal of Laboratory Medicine

摘　　要：免疫系统在 HBV 慢性感染的病程和转归中发挥着重要作用。慢性乙型肝炎(CHB)患者体内免疫功能异常,主要表现为抗 HBV 的特异性细胞免疫功能低下,同时伴有不同程度的树突状细胞(DC)、CD4辅助性 T 细胞(Th)、CD_8细胞毒性 T 细胞(CTL)功能损伤,调节性 T 细胞(Treg)细胞数量增加以及 PD-L1/PD-1抑制途径异常活跃等方面。同时,临床免疫学检测和研究对于 CHB 病程各阶段的免疫状态的判断,指导抗病毒治疗和评价疗效以及建立新的免疫治疗策略都有重要意义。Host＇s immune responses play a crucial role in influencing the disease progression and outcome of hepatitis B virus （HBV） infection Chronic states of hepatitis B patients have been linked to aberrant immune function. HBV specific cellular immune responses are dysfunctional in chronic HBV infected patients, which included various degree of decrease and functional impairment of dendritic cells, CD4 helper T cells （ Th）, CDs cytotoxic T lymphocytes （CTL） as well as increase of regulatory T cells （Treg） and enhanced PD-L1/PD-1 signal pathway among immunocytes. The research and assay of clinical immunology could facilitate assessing of the immune status of infection process of the hepatitis B, guidance of chnical antivirus therapies and development of novel immunetherapeutic strategies for patients with chronic HBV infection.

关 键 词：肝炎病毒 乙型 树突状细胞 调节性T细胞 

分 类 号：R512.6[医药卫生—内科学]