灰毡毛忍冬中皂苷类成分的研究  

Saponins from flower buds of Lonicera macranthoides

作　　者：贾晓东[1] 冯煦[1] 董云发[1] 赵兴增[1] 王鸣[1] 赵友谊[1] 孙浩[1] 

机构地区：[1]江苏省中国科学院植物研究所南京中山植物园江苏省药用植物研究开发中心,江苏南京210014

出　　处：《中草药》2007年第10期1452-1455,共4页Chinese Traditional and Herbal Drugs

基　　金：江苏省社会发展科技计划(BS2001025)

摘　　要：目的研究灰毡毛忍冬Lonicera macranthoides花蕾的化学成分。方法灰毡毛忍冬药材90%乙醇提取液依次用石油醚和醋酸乙酯萃取,醋酸乙酯萃取部分反复柱色谱得到化合物。结果从灰毡毛忍冬花蕾中分离鉴定了6个皂苷类化合物:3-O-β-D-吡喃葡萄糖基(1-4)-β-D-吡喃葡萄糖基(1-3)-α-L-吡喃鼠李糖基(1-2)-α-L-吡喃阿拉伯糖基-常春藤皂苷元-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖酯苷(Ⅰ)、3-O-β-D-吡喃葡萄糖基(1-3)-α-L-吡喃鼠李糖基(1-2)-α-L-吡喃阿拉伯糖基-常春藤皂苷元-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖酯苷(Ⅱ)、3-O-α-L-吡喃阿拉伯糖基-常春藤皂苷元-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖酯苷(Ⅲ)、3-O-β-D-吡喃葡萄糖基(1-4)-β-D-吡喃葡萄糖基(1-3)-α-L-吡喃鼠李糖基(1-2)-α-L-吡喃阿拉伯糖基-常春藤皂苷元(Ⅳ)、3-O-β-D-吡喃葡萄糖基(1-3)-α-L-吡喃鼠李糖基(1-2)-α-L-吡喃阿拉伯糖基-常春藤皂苷元(Ⅴ)、3-O-α-L-吡喃鼠李糖基(1-2)-α-L-吡喃阿拉伯糖基-齐墩果酸-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖酯苷(Ⅵ)。结论化合物Ⅲ为首次从忍冬属植物中分得,Ⅳ、Ⅴ为首次从该植物中分得,Ⅵ为首次从该植物中分得的齐墩果酸型皂苷。Objective To study the chemical constituents from flower buds of Lonicera rnacranthoides. Methods The 90% EtOH extract of L. macranthoides was successively extracted with petroleum ether and ethyl acetate. The following compounds （ Ⅰ-Ⅵ ） were obtained by repeated column chromatography of the ethyl acetate fraction. Results Six saponins were isolated from the flower buds of L. macranthoides and identified as： 3-O-β-D-glucopyranosyl （1-4）-β-D-glucopyranosyl （1-3）-α-L-rhamnopyranosyl （1-2）-α- L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl- （1-6）-β-D-glucopyranoside （ Ⅰ ） ; 3-O-β-D-glucopyranosyl （1-3）-α-L-rhamnopyranosyl （1-2）-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyra- nosyl- （1-6）-β-D-glucopyranoside （ Ⅱ ） ; 3-O-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-（1-6）-β-D-glucopyranoside （ Ⅲ） ; 3-O-β-D-glucopyranosyl （ 1-4）-β-D-glucopyranosyl （1- 3）-α-L-rhamnopy- ranosyl （1-2）-α-L-arabinopyranosyl-hederagenin （ Ⅳ ） ; 3-O-β-D-glucopyranosyl （1-3）-α-L-rhamnopyra-nosyl （1-2）-α-L-arabinopyranosyl-hederagenin （Ⅴ） ; 3-O-α-L-rhamnopyranosyl （1-2）-α-L-arabinopyra- nosyl oleanolic acid 28-O-β-D-glucopyranosyl-（1-6）-β-D-glucopyranoside （Ⅵ）. Conclusion Compound illis first isolated from the plants of Lonicera L. , compounds Ⅳ and Ⅴ are isolated from this plant for the first time, and compound Ⅵ is an oleanolic acid saponin isolated from this plant for the first time.

关 键 词：灰毡毛忍冬 常春藤皂苷 齐墩果酸型皂苷 

分 类 号：R284.1[医药卫生—中药学]