STEM-X对糖尿病大鼠超氧化物歧化酶活力的影响  

The effect of STEM-X on activity of SOD in DM rats

作　　者：宗凯[1] 杜光[1] 陈云舟[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,湖北武汉430030

出　　处：《中国医院药学杂志》2007年第10期1402-1403,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察STEM-X对糖尿病大鼠血糖及超氧化物歧化酶(SOD)活力的作用。方法:SD大鼠禁食12h后,按50mg.kg-1体质量一次性腹腔注射链脲佐菌素溶液,建立糖尿病大鼠模型。72h后,以空腹血糖≥15mmol.L-1,作为造模成功的筛选标准。随机分成STEM-X高剂量组、低剂量组和模型组,每组9只。另取10只正常血糖大鼠作为空白组。每7天测一次空腹血糖,4周后禁食12h采血测定SOD。结果:与模型组比较,STEM-X可使血糖降低,但差异无显著性(P>0.05),能显著提高SOD活力(P<0.05)。结论:STEM-X对糖尿病大鼠血糖无明显作用,但能显著提高SOD活力,具有较强的抗氧化能力。OBJECTIVE To probe the effect of STEM-X on blood glucose and superoxide dismutase （SOD） activity in serum in diabetes mellitus （DM） rats. METHODS DM animal model was made with streptozotocin （STZ, 5（11 mg·kg^-1 ） abdominal injection. 72 h later, rats of blood-fasting glucose level ≥5 mmol·L^-1 were regarded as DM model. Rats were at random divided into 3 groups with 9 rats in each group： STEM-X low dose group, high dose group and model control group. And normal control group was composed of other 10 normal rats, The blood-fasting glucose levels were measured once a week. 4 weeks later the activity of SOD in blood serum was measured after fasting for 12 h. RESULTS STEM-X could decrease the blood glucose level, but it has no significant difference （P〉0. 05）. It could markedly increase the activity of SOD （P-0. 05）. CONCLUSION STEM-X had no obvious effect on blood glucose level in DM rats, but it can markedly increase the activity of SOD in blood serum in DM rats. It indicates that STEM-X has strong antioxidation function.

关 键 词：STEM-X 糖尿病 超氧化物歧化酶 

分 类 号：R969[医药卫生—药理学]