转基因修复椎间盘细胞外基质的研究进展  

ADVANCES OF RESEARCH ON REPAIR OF DEGENERATIVE INTERVERTEBRAL DISC WITH GENE TRANSDUCTION

作　　者：赵献峰[1] 刘浩[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2007年第10期1104-1107,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30572163)~~

摘　　要：目的综述转基因修复退变椎间盘细胞外基质(extracellular matrix,ECM)的发展及研究进展。方法广泛查阅近年来有关转基因调节椎间盘ECM合成和分解的国内外文献,并进行综述。结果椎间盘正常的形态、功能与ECM的合成、降解密切相关。ECM已经成为转基因修复退变椎间盘的标靶。转基因治疗目前在载体的选择、靶基因的转导、转入基因的调控与安全性等多方面取得明显进展。结论转基因修复退变椎间盘是治疗椎间盘退变性疾病的重点研究方向。Objective To introduce the latest advances of research on repair of the degenerative intervertebral disc with gene transduction. Methods The recently-published articles about the treatment of degenerative disc with gene transduction were reviewed, especially the articles published during the recent 5 years about the application of this therapy to regulating the synthesis and degradation of the extracellular matrix of the degenerative intervertebral disc. Results The shape and function of the normal intervertebral disc were reported to be closely related to the synthesis and degradation of the extracellular matrix of the intervertebral disc. The extracellular matrix of the intervertebral disc was a target for the gene transduction to repair the degenerative intervertebral disc. There was a great development of the treatment with gene transduction, especially in vector choice, target gene transduction, and transgene regulation and safety. Conclusion The advances of the research have indicated that repair of the degenerative intervertebral disc with gene transduction is a key to curing the disease of the degenerative intervertebral disc.

关 键 词：基因转导 椎间盘 细胞外基质 修复 综述 

分 类 号：R681.5[医药卫生—骨科学] Q78[医药卫生—外科学]