老年中、重度慢性阻塞性肺疾病患者气道可逆性比较  

Differences of airway reversibility between moderate and severe chronic obstructive pulmonary disease in elder patients

作　　者：王兆美[1] 杨汀[1] 张黎明[1] 

机构地区：[1]首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科,北京100043

出　　处：《内科理论与实践》2007年第5期336-338,共3页Journal of Internal Medicine Concepts & Practice

摘　　要：目的:探讨老年中、重度慢性阻塞性肺疾病(COPD)患者气道阻塞的可逆性,并进行比较。方法:入选46例老年中度COPD稳定期患者和42例老年重度COPD稳定期患者,测定其吸入硫酸沙丁胺醇前后肺通气功能,观察各通气指标改善情况,计算改善率并进行比较。结果:中度COPD组和重度COPD组患者吸药后的肺功能均有一定改善,但重度COPD患者的呼气峰流速(PEF)、一秒钟用力呼气量(FEV1)、最大呼气中段流量(MEF25-75)等指标的改变率显著小于中度COPD组(P<0.05);重度COPD患者中有4.76%支气管舒张试验阳性,而中度COPD患者中36.96%支气管舒张试验阳性。结论:部分COPD患者气道阻塞具有一定可逆性,但老年重度COPD患者的气道可逆程度明显低于老年中度COPD患者。Objective To compare the differences of airway reversibility between moderate and severe chronic obstructive pulmonary disease（COPD） in elder patients. Methods Forty-six moderate and 42 severe senile COPD patients were enrolled into this study. All these patients were in stable status. Airway reversibility was evaluated based upon the changes in forced expiratory volume in one second （FEV1） and peak expiratory flow （PEF） after salbutamol （400μg） inhalation. The parameters of lung function were simultaneously compared between these two groups prior to and after salbutamol inhalation. Results After salbutamol inhalation, the values of PEF, FEV1 and maximum expiratory flow （MEF）25-75 were ameliorated in both groups. But the ranges of change were smaller in severe group than those in moderate group （P〈 0.05）. The percentages of patients demonstrated positive airway reversibility in severe and moderate group were 4.76% and 36.96%, respectively. Conclusions Airflow limitation in some elder COPD patients were reversible. Yet, the airway reversibility was less in severe COPD patients than those in moderate ones.

关 键 词：老年人 慢性阻塞性肺疾病 气道可逆性 

分 类 号：R563.9[医药卫生—呼吸系统]