幽门螺杆菌感染对胃黏膜解痉多肽和ERK表达的影响  

Effects of Helicobacter Pylori Infection on the Expression of SP and ERK in the Gastric Mucosa

作　　者：穆标[1] 刘之武[1] 王志川[1] 谢蓓[1] 吕梦华[1] 骆元正[1] 雷晶[1] 邢燕[1] 崔海沫[1] 秦怡男[1] 

机构地区：[1]天津市公安医院,300042

出　　处：《天津医药》2007年第10期751-752,共2页Tianjin Medical Journal

摘　　要：目的:探讨幽门螺杆菌(Hp)在Hp相关性胃炎的发病机制中对胃黏膜上皮细胞解痉多肽(SP)以及细胞外信息相关蛋白激酶(ERK)表达的影响。方法:检测68例浅表性胃炎患者的活检组织标本。(1)采用免疫组织化学和染色评分的半定量法对Hp阳性组与阴性组、Hp根除前和根除后慢性浅表性胃炎患者的胃黏膜上皮细胞的SP和ERK的表达量进行检测比较。(2)采用质子泵抑制剂+克拉霉素+甲硝唑三联疗法根治Hp感染。结果:(1)Hp阳性组SP和ERK的表达量较阴性组明显减少(P<0.05)。(2)Hp根除后SP和ERK的表达量较根除前明显增加(P<0.05)。结论:SP和ERK表达量的异常在Hp致胃黏膜损害的发病机制中起重要作用。Objective： To investigate the possible role of spasmolytic polypeptide （SP）and extracellular signal regulated protein kinase （ERK）in the pathogenesis of helicobacter pylori （H pylori）relaed gastritis. Methods： The expression of SP and ERK were detected by immunochemical technique in patients of H pylori positive, H pylori negative and those before and after eradication of H pylori, respectively. Results： The expression of SP and ERK in the H pylori positive group were significantly lower than those of H pylori negative group. The expressions of SP and ERK were significatly increased after H pylori eradication （P 〈 0.05 ）. Conclusion： Abnormal expression of SP and ERK may play a key role in the pathogenesis of H pylori related gastritis.

关 键 词：螺杆菌 幽门 螺杆菌感染 肽类 细胞外信号调节MAP激酶类 胃黏膜 

分 类 号：R446.5[医药卫生—诊断学]