壮族人群寻常型银屑病HLA-DRB1基因分型  

A CORRELATIVE STUDY OF PSORIASIS VULGARIS WITH HLA-DRB1 LOCUS AMONG GUANGXI ZHUANG POPULATION

作　　者：郑文军[1] 温斯健[1] 林有坤[1] 严煜林[1] 潘尚领[2] 甘瑞静[2] 陈文成[3] 

机构地区：[1]广西医科大学第一附属医院皮肤科,南宁530021 [2]广西医科大学病理生理学教研室 [3]右江民族医学院附属医院检验科

出　　处：《广西医科大学学报》2007年第4期534-536,共3页Journal of Guangxi Medical University

基　　金：广西科学基金资助项目(No.桂科自0342009-5)

摘　　要：目的：探讨广西壮族寻常型银屑病患者的发病与HLA-DRB1基因的关联。方法：应用聚合酶链式反应—序列特异引物（PCR-SSP）法对58例壮族寻常型银屑病患者和102例健康壮族人的HLA-DRB1座位进行基因分型,比较两组相应等位基因的频率。结果：两组被检者在设计的15对引物中检出12个等位基因,其中以HLA-DRB1＊15和HLA-DRB1＊16的频率最高,HLA-DRB1＊07在银屑病组的频率明显高于对照组（OR=0.330,CI=0.123-0.880,P=0.022）,其它等位基因频率在两组间差异无统计学意义（P〉0.05）。结论：HLA-DRB1＊07与广西壮族人寻常型银屑病的关系密切,可能为该人群银屑病的易感因子之一。Objective： To investigate the association of HLA-DRB1 locus and the pathogenesis of psoriasis vulgaris in Guangxi Zhuangs. Methods：58 Guangxi Zhuang patients with psoriasis vulgaris （PV） and 102 healthy controls were genotyped for HLA-DRB1 locus by using polymerase chain reaction-sequence specific primer （PCR-SSP） technique and allelic frequencies were analyzed between the two groups. Results： 12 alleles were detected in the two groups with the 15 pairs of designed primers, in which HLA-DRB1 ＊ 15 and -DRB1 ＊ 16 were the most frequent alleles. The frequency of HLA-DR ＊ 7 was found significantly higher in PV group than that of control group （ OR ：0. 330,CI=0. 123-0. 880, P =0. 022）. No difference was found on other alleles in the locus between the two groups. Conclusion： HLA-DRB1 ＊ 07 has close relationship with the pathogenesis of psoriasis vulgaris and might be one of the susceptible factors of the disorder among Guangxi Zhuang population.

关 键 词：银屑病 壮族 广西 HLA 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]