泮库溴铵的合成  

The synthesis of pancuronium bromide

作　　者：王玉成[1] 陈玉芳[2] 顾菲[2] 辜顺林[2] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050 [2]徐州师范大学化学系,徐州221116

出　　处：《中国新药杂志》2007年第19期1599-1602,共4页Chinese Journal of New Drugs

摘　　要：目的:合成中长效非去极化型肌松药泮库溴铵。方法:以5α-雄甾-2-烯-17-酮为起始原料经酯化、氧化、开环、还原、乙酰化,最后与溴甲烷成盐等6步反应合成泮库溴铵。结果:泮库溴铵的结构经核磁共振谱确证,总收率为22.1%。结论:本路线可简化实验操作,降低成本,适合工业化生产。Objective： To study the synthesis of pancuronium bromide. Methods： Pancuronium bromide was synthesized from 5-androst-2-en-17-one through esterifieation, oxidation, ring opening, reduction, aeetylation and then reacted with bromomethane. Results ： The structure of paneuronium bromide was verified by 1^H-NMR and 13^C-NMR. The overall yield was 22.1%. Conclusion：This cost-saving and simplified method can be used in the industrial manufacture.

关 键 词：泮库溴铵 肌松药 药物合成 

分 类 号：R971.8[医药卫生—药品] R914.5[医药卫生—药学]