脑清灵汤治疗抽动秽语综合征的作用及机理研究  

Effects and Mechanism of Naoqingling Decoction on Gilles de la Tourette Syndrome

作　　者：朱晓燕[1] 周大兴[1] 倪世美[1] 阮叶萍[1] 王晶[1] 顾静[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《浙江中医药大学学报》2007年第5期565-566,共2页Journal of Zhejiang Chinese Medical University

基　　金：浙江省中医药管理局(No:2005-84)~~

摘　　要：[目的]探讨脑清灵汤对抽动秽语综合征(TS)的治疗作用及作用机制。[方法]采用苯丙胺诱发小鼠拟TS模型,观察各组小鼠定型活动和自主活动情况,测定脑内单胺类神经递质如多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)及5-羟吲哚乙酸(5-HIAA)的含量。[结果]脑清灵汤能对抗苯丙胺诱发的定型活动;能明显减少TS模型小鼠的自主活动;能显著降低TS模型小鼠纹状体中DA、NE、5-HT及5-HIAA的含量。[结论]脑清灵汤对TS动物模型有治疗作用,作用机制可能是其影响脑内单胺类神经递质的分泌代谢。[Objective] To elucidate the effects and mechanism of Naoqingling Decoction （ND） on Gilles de la Tourette syndrome （TS）. [Method]Central nervous system of mice was stimulated by amphetamine（AMP）to develop the model of experimental tourette syndrome （ETS）. Then we observed the stereotypia and autonomic activities of mice, and determined the levels of monoamine neurotransmitters such as dopamine （DA）, norepinepbrine （NE）, 5-hydroxytryptamine （5-HT） and 5-bydroxyindoleacetic acid（5-HIAA） in the brains. [Resuh] To compare with model group,three-dose ND groups can resist the determinate activities stimulated by AMP;can obviously decrease the autonomic activities of mice and degrade the levels of DA, NE, 5-HT and 5- HIAA in the corpora striates. [Conclusion] ND has therapeutical effect on ETS model and it＇s mechanism may be its effects on the secretion or metabolism of neurotransmitter in the brains.

关 键 词：脑清灵汤 抽动秽语综合征 小鼠 

分 类 号：R285.5[医药卫生—中药学]