中生菌素的抗生作用  

THE ANTIBIOTIC ACTION OF ZHONGSHENGMYCIN

作　　者：蒋细良[1] 谢德龄[1] 倪楚芳[1] 朱昌雄[1] 宋培国[1] 

机构地区：[1]中国农科院生防所

出　　处：《植物病理学报》1997年第2期133-138,共6页Acta Phytopathologica Sinica

摘　　要：本文研究了中生菌素对革兰氏阳性菌、革兰氏阴性菌、丝状真菌的抗生作用。结果表明，中生菌素是一种抗菌谱比较广的农用抗生素。其对菌体细胞膜无明显的影响。１００ｐｐｍ时引起部分菌体原生质凝聚。同位素标记前体物掺入实验表明，中生菌素１５．６ｐｐｍ对白菜软腐病菌ＤＮＡ、ＲＮＡ的合成影响很小，但强烈抑制菌体蛋白质的合成。用化学测定法分析了中生菌素对枯草杆菌细胞内大分子物质含量的影响，得到了和前体物掺入法相似的结果。The inhibiting action of ZHONGSHENGMYCIN on gram postive bacteria, gram negative bacteria and filamentous fungi showed that ZHONGSHENGMYCIN was a wide spectrum agricultural antibiotics. It had no effect on permeability of cell membrane of bacteria, but it could result in condensation of the plasma of some cells of E. carotovora subsp. carotovora on high concentration 100 ppm. The incorporation experiment of precursor labelled by radio active isotope showed that ZHONGSHENGMYCIN had little effect on the synthesis of DNA and RNA of E. carotovora subsp. carotovora on 15.6 ppm, while it had strong inhibiting action on the synthesis of protein. Similar results to precursor incorporation experiment was gained by quantity analysis the amount of the macromolecules of Bacillus subtilis 6633. The studies showed the mode of action of ZHONGSHENGMYCIN is the inhibiting action on the synthesis of protein.

关 键 词：中生菌素 作用机制 前体物 抗菌素 农药 

分 类 号：S482.7[农业科学—农药学]