持续皮下胰岛素输注对2型糖尿病早期胰岛功能改善作用的临床研究  

Clinical study on improving islet function of early stage of type 2 diabetes with Continuous Subcutaneous insulin infusion

作　　者：武明东[1] 

机构地区：[1]上海中医药大学附属曙光医院急诊科

出　　处：《临床内科杂志》2007年第10期679-681,共3页Journal of Clinical Internal Medicine

摘　　要：目的 探讨初发的2型糖尿病患者，应用持续皮下胰岛素输注（CSⅡ）或多次胰岛素皮下注射（MSⅡ）的治疗，对胰岛8细胞功能和血糖的影响。方法 CSⅡ组采用持续皮下胰岛素输注形式，在3天内使血糖达标；MSII组采用小剂量起步，平均2～3周逐步将血糖调整到位的方法，观察治疗前后血糖、血浆C肽（C-P）空腹、餐后1小时、2小时及HbAlc的变化。结果 两组的血糖及HbAlc较治疗前明显下降（P〈0．05），而CSⅡ组下降更为明显（P〈0．05），且该组C．P空腹及餐后1小时值有所升高（P〈0．05），胰岛素用量也较MSⅡ组有所减少。结论 对初诊的血糖较高的2型糖尿病患者尽早应用持续皮下胰岛素输注的方式，更有助于将血糖控制在理想水平及改善胰岛功能。Objective To investigate the effet of islet function and hyperglycemia of early stage of type 2 diabetes with Continuous subcutaneous insulin infusion （CSⅡ） and Multiple subcutaneous insulin injection（MSⅡ）. Methods The hyperglycemia of CSⅡ group was correted by intensive insulin pump within 3 days ,and MSⅡ group was targeted in 2-3 weeks. Blood glucose ,0,60,120 minutes C-peptide（ C- P） and HbAlc were compared. Results Blood glucose and HbAlc was significantly decreased in CSⅡ group（ P 〈 0.05）, at the same time ,0 and 60 minutes C-P was increased（ P 〈 0.05 ）, the total insulin administration dose in CSⅡ group was lower than MSⅡ group. Conclusions For early stage of type 2 diabetes mellitus patients with hyperglycemia, CSⅡ is more efficient than MSⅡ in targeted blood glucose and improving the function of 13cells,it is the ideal method of insulin therapy.

关 键 词：持续皮下胰岛素输注 糖尿病 胰岛功能 高血糖 胰岛素皮下注射 

分 类 号：R587.1[医药卫生—内分泌]