补肾化瘀祛痰方治疗多囊卵巢综合征的临床研究  

Clinical Study on Effect of Bushen Huayu Qutan Recipe in Treating Polycystic Ovarian Syndrome

作　　者：吴建辉[1] 俞超芹[1] 周巧玲[1] 韩洁[1] 王针织[1] 沈慰[1] 

机构地区：[1]第二军医大学附属长海医院中西医结合科,上海200433

出　　处：《中国中西医结合杂志》2007年第10期883-886,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的了解补肾化瘀祛痰方治疗多囊卵巢综合征的临床疗效及可能的作用机制。方法以补肾化瘀祛痰中药为主的水煎内服方及外敷方(必要时联合西药二甲双胍)治疗多囊卵巢综合征46例,连续治疗6个月为1个疗程;观察治疗前后临床症状和体征(肥胖、多毛、痤疮及黑棘皮症评分)、血清激素水平及胰岛素释放试验的变化情况。结果治疗后患者多毛、痤疮、黑棘皮症评分值及肥胖评分值与治疗前比较均明显下降(P<0.01,P<0.05);血清睾酮(T)水平较治疗前显著降低(P<0.05);胰岛素试验中空腹胰岛素值与治疗前比较下降(P<0.01),糖负荷后30min、60min胰岛素值及胰岛素曲线下面积(IAUC)与治疗前比较亦有明显下降(P<0.05)。结论以补肾化瘀祛痰方可以显著改善多囊卵巢综合征患者的症状和体征,改善患者的卵巢功能。Objective To investigate the therapeutic effect and the possible mechanism Qutan Recipe （BHQR, a Chinese recipe formulated according to the therapeutic principle of resolving stasis and dispelling phlegm） on polycystic ovarian syndrome （PCOS）, Methods of Bushen Huayu nourishing Shen, BHQR was used, both internally and externally, to treat 46 patients with PCOS, and combined with diformin if necessary. Six successive months treatment was regarded as one course. The clinical symptoms and signs, including obesity, polytrichia, ache and acanthosis, were observed and scored before and after treatment; and serum levels of hormones and insulin were measured as well. Results After treatment, the scores of symptoms and signs of patients were significantly lowered （P 〈 0.05 for obesity and P 〈 0.01 for others）, significant lowering was also found in serum level of testosterone （P〈0.05）, fasting serum insulin （P〈0.01） and the values of insulin and insulin area under curve （P 〈0.05） 30 rain and 60 min after glucose load. Conclusion BHQR could not only significantly relieve the symptoms and signs of patients with PCOS, but also regulate well the ovarian function.

关 键 词：多囊卵巢综合征 补肾化瘀祛痰方 青春期 育龄期 

分 类 号：R271.9[医药卫生—中西医结合]