乙型肝炎疫苗免疫19年后乙型肝炎病毒感染流行规律的变化  

Variations of hepatitis B virus infection epidemic pattern after long-term HBV vaccine immunization

作　　者：沈立萍[1] 杨进业[1] 莫兆军[1] 李荣成[1] 李艳萍[1] 韦增良[1] 董邕辉[1] 周开姣[1] 韦少超[2] 方孔雄[2] 余陶[3] 张文英[3] 张勇[3] 毕胜利[3] 

机构地区：[1]广西壮族自治区疾病预防控制中心,南宁530021 [2]隆安县疾病预防控制中心 [3]中国疾病预防控制中心病毒病预防控制所

出　　处：《中华实验和临床病毒学杂志》2007年第3期253-255,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：广西壮族自治区医疗卫生重点科研课题（重200511）

摘　　要：目的探讨乙肝疫苗长期免疫地区人群HBV流行规律的变化趋势。方法整群抽样结合横断面调查，用固相放射免疫法检测研究对象血清HBV感染标志并进行分析。结果（1）平均HBsAg阳性率为7．5％，0～19岁人群HBV感染指标显著低于≥20岁人群。（2）0～19岁人群HBsAg阳性率1985年高于2005年；1985年的抗-HBs水平随着年龄增长而上升，从1～岁组的12．4％到60～岁组的53．8％，而2005年0～19岁组的抗-HBs随着年龄的增长而下降；1985年抗-HBc阳性水平随着年龄增长而上升，2005年的0～19岁组的仅为2．8％～26．8％，显著下降。结论研究人群中HBV流行规律发生显著变化，0～19岁人群的HBV感染率远低于20岁以上人群，证实乙肝疫苗预防HBV感染取得显著成果。Objective To study the epidemic pattern and trend of HBV infection in the area where the people had been immunized by HBV vaccine for two decades. Methods The whole sampling method was applied in combination with cross-sectional investigation. Blood samples were taken from every member of families. Markers of HBV infection were determined by using solid-phase radioimmunoassay （ SPR1A）. Results （ 1 ） The average HBsAg positive rate was 7.5 %. The positive rate of markers for HBV infection of 0-19 years old subjects were lower than those of≥ 20 years old subjects. （2） The positive rate of HBsAg of 0-19 years old subjects in 1985 was higher than that in 2005. The anti-HBs positive rate in 1985 stemded to be higher with age. It was 12.4% in 1- age group to 53.8% in 〉 60 years age group. While the result of 2005 showed that the anti-HBs positive rate of 0- 19 years old subjects dropped with age. The anti-HBc positive rate in 1985 also tended to be rising with age. But the result of 2005 showed that the rate of 0-19 years old subjects wa~ just 1.4% to 16.8 %. Conclusions The epidemic patterns of HBV infection have had significant variations in the target population. HBV vaccine immunization has obtained excellent efficacy.

关 键 词：肝炎 乙型 接种 流行病学 

分 类 号：R181[医药卫生—流行病学] R51[医药卫生—公共卫生与预防医学]