医院感染凝固酶阴性葡萄球菌分布及耐药性分析  

Nosocomial Infection and Resistance of Coagulase Negative Staphylococcus

作　　者：庞杏林[1] 郑桂丽[1] 李孝权[1] 邓志爱[1] 莫自耀[1] 

机构地区：[1]广州市疾病预防控制中心,广东广州510080

出　　处：《中华医院感染学杂志》2007年第10期1289-1291,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析医院感染凝固酶阴性葡萄球菌(CNS)的分布及耐药性。方法对临床分离的CNS进行鉴定,以K-B法检测药敏,Nitrocefin色原法测定β-内酰胺酶,刚果红平板法检测黏质。结果在162株CNS中,检出表皮葡萄球菌83株,占51.2%;耐苯唑西林凝固酶阴性葡萄球菌(MRCNS)102株,100.0%产β-内酰胺酶,黏质阳性率17.6%;苯唑西林敏感凝固酶阴性葡萄球菌(MSCNS)60株,5.0%产β-内酰胺酶,黏质阳性率1.7%;MRCNS对12种抗菌药物耐药性明显高于MSCNS(P<0.01);所有CNS对万古霉素敏感。结论CNS已为重要医院感染菌;CNS耐药性增高与产β-内酰胺酶和黏质有关;临床应积极进行病原学和耐药性监测,合理用药。OBJECTIVE To study the distribution and drug resistance of coagulase negative Staphylococcus （CNS） that leads to nosocomial infection. METHODS Nosocomial CNS was identified and then drug resistance test was performed by K-B method. Nitrocefin method and the Congo red method were utilized to detect β-lactamase and the slime,respectively. RESULTS Of all 162 CNS strains isolated, there were 102 strains of MRCNS and 60 strains of MSCNS including 83 S. epidermidis strains, accounting for 51. 2%. Among all the MRCNS and MSCNS strains above, the positive rates of the β-lactamase were 100. 0% and 5. 0%, respectively, and the positive rates of the slime were 17.6% and 1.7%, respectively. The resistance rates of MRCNS to 12 types of antibiotics were higher than those of MSCNS（P〈0. 01）. All CNS was sensitive to vancomycin. CONCLUSIONS CNS is increasingly playing a significant role in nosocomial infection. The elevation of drug resistance of CNS has relations with β-lactamase and the slime. To control this kind of nosocomial infection, it is critically important to monitor the antimicriobial resistance of CNS.

关 键 词：医院感染 凝固酶阴性葡萄球菌 Β-内酰胺酶 黏质 耐药性 

分 类 号：R378.11[医药卫生—病原生物学]