尸体肾移植术后延迟应用环孢素A的临床研究  

Clinical study on delayed regiment of CsA in cadaveric renal transplantation

作　　者：王长希[1] 郑克立[1] 吴培根[2] 

机构地区：[1]中山医科大学附属一院泌尿外科,广州510080 [2]中山医科大学附属一院肾内科,广州510080

出　　处：《中华肾脏病杂志》1997年第2期82-84,共3页Chinese Journal of Nephrology

摘　　要：目的 探讨肾移植术后延迟应用环孢素A(CsA)并结合预防性使用抗人淋巴细胞球蛋白(ALG)的四联免疫抑制剂顺序用药对移植肾早期功能的影响。方法 观察并比较90例延迟应用CsA的四联顺序用药(实验组)和215例肾移植术后立即应用CsA(对照组)的近期疗效。结果 实验组移植肾功能恢复快(P<0.01),急性肾小管坏死(ATN)发生率明显降低(P<0.01);两组急性排斥及巨细胞病毒感染发生率均无显著性差异(P>0.05)。结论 肾移植术后延迟应用CsA并结合预防性应用ALG是一种理想的用药方案。Objective To study the effect of delayed cyclosporine(CsA) therapy combined with prophylactic use of antilympho-cyte globulin (ALG) (sequential quadruple immunosuppressive protocol) on early graft function in renal transplantation. Methods The experimental group included 90 renal recipients who were treated with posttransplant quadruple sequential therapy. Their short-term outcomes were compared with those of 215 recipients who were given CsA immediately after transplantation(control group). Results Not only was the recovery of renal allograft function faster in the experimental group ( P <0.01), but also the incidence of acute tubular necrosis (ATN) was lower ( P <0.01). In addition, the oc-curence of acute rejection and cytomegalovirus (CMV) was not significantly higher in the experimental group ( P >0. 05). Conclusion Delayed CsA therapy in conjunction with prophylactic use of ALG is a desirable protocol for treating posltransplant renal recipients.

关 键 词：肾移植 环孢素A 抗人淋巴细胞 球蛋白 

分 类 号：R699.207[医药卫生—泌尿科学] R979.5[医药卫生—外科学]