肾性高血压患者血尿内皮素水平变化及意义  

The significance and changes of plasma endothelin-i and urinary excretion rate of endothelin in patients of chronic glomerulonephritis with renal hypertension

作　　者：熊祖应[1] 乔孝儒[1] 梁维龙[1] 郝丽[1] 卢文[1] 戴宏[1] 

机构地区：[1]安徽医科大学第一附属医院肾脏科,合肥230022

出　　处：《中华肾脏病杂志》1997年第2期89-91,共3页Chinese Journal of Nephrology

摘　　要：目的 探讨内皮素在肾性高血压及肾脏病发展中所起的作用。方法 检测了正常人、慢性肾小球肾炎患者血浆内皮素(PET-1)和24小时尿内皮素排泄量(UET-1),内生肌酐清除率(Ccr)和尿β_2微球蛋白(β_2-m)。结果 所有患者PET-1和UEP-1水平均升高;且PET-1或UET-1与平均动脉压(MAP)和β_2-m呈正相关,与Ccr呈负相关。结论 内皮素参与肾性高血压形成和肾脏病进展,且UET-1是肾小管功能损害的一个指标。Objective To elucidate the effects on renal hypertension and progressive renal disease of endothelin-1 in patients of chronic glomerulonephritis. Methods Plasma endothelin-1 (PET-1 )N urinary excretion rate of endothelin-1 (UET-1 )., creatinine clearance (Ccr) and urinary excretion rate of 2-microglobulin (β2-m) in 27 patients with chronic glomerulonephritis and in 10 normal control were measured. Results The level of PET-1 and UET-1 in all patients was markedly elevated. Positive correlation between PET-1 or UET-1 and mean artery pressure (MAP) or β2-m, negative correlation between PET-1 or UTE-1 and Ccr were found. Conclusion Endothelin plays an important role in developing renal hypertension and in progressive renal diseases, and also UET-1 is a sensitive marker of renal tubular damage.

关 键 词：内皮素 肾性高血压 内生肌酐清除率 β_2微球蛋白 

分 类 号：R544.140.2[医药卫生—心血管疾病] R362[医药卫生—内科学]