1984-2005年台州市肾综合征出血热监测研究  

Study and surveillance on hemorrhagic fever with renal syndrome in Taizhou city from 1984 to 2005

作　　者：刘令初 陈忠妙[1] 崔清荣 姚兆华[2] 张东其 傅桂明[3] 

机构地区：[1]浙江省台州市疾病预防控制中心,台州318000 [2]天台县疾病预防控制中心 [3]浙江省疾病预防控制中心

出　　处：《中国媒介生物学及控制杂志》2007年第5期404-407,共4页Chinese Journal of Vector Biology and Control

摘　　要：目的掌握台州市肾综合征出血热（HFRS）人间和动物间疫情动态变化，有针对性地采取防制对策。方法选择天台、仙居监测点和部分县（市、区）疫源地调查点，开展人间和宿主动物HFRS疫情监测，采用间接免疫荧光法检测抗体，直接免疫荧光法检测抗原。结果1984—2005年台州市共报告HFRS病人13752例，年均发病率11．90／10万，以1986年发病率最高为34．85／10万，天台县发病例数和发病率均居全市首位；以11月至次年1月为发病高峰，46月有发病小高峰，发病曲线呈双峰型；20～49岁发病数占66．57％，男女之比为2．58：1，农民发病占80．95％。疑似病人和临床诊断病人诊断符合率68．72％，健康人群隐性感染率3、13％。小兽总密度10．94％，野外密度13．07％，明显高于居民区（8．79％）（P〈0．叭）。小兽种群分布共2目16种，野外以黑线姬鼠为优势种，占76．89％；居民区以褐家鼠为优势种，占77．37％。黑线姬鼠和褐家鼠带病毒率分别为4．48％和3．95％，带病毒鼠指数分别为0．044和0．036。小兽密度季节消长、带病毒率季节分布和带病毒鼠指数季节分布与人间疫情季节分布基本吻合，均出现11月至次年1月和4—6月冬、春季高峰。以冬峰为主。病人血清和鼠肺抗原分型，姬鼠（Ⅰ）型分别占60．91％和53．52％，家鼠（Ⅱ）型分别占32．51％和37．42％，未定型分别占6．58％和9．06％。结论台州市属以姬鼠型为主的混合型HFRS疫区，鼠密度和带病毒率较高，宜采取双价HFRS疫苗接种和灭鼠防鼠为主的综合性防制措施。Objective To understand the epidemic dynamic of hemorrhagic fever with renal syndrome（HFRS） which was in humans and animals in Taizhou city for preventive measures against the disease. Methods Choose the surveillant aera of Tiantai and Xianju, and the epidemic foci of the other counties as surveillance of epidemic of HFRS in humans and host animal, and use the indirect immunofluorescence assay to determine the antiboby and direct immunofluorescence assay to determine the antigen. Results 13 752 cases had been reported from 1984 to 2005 in Taizhou city, and the annual incidence was 11.90/ 100 000. The incidence 34.85/100 000 of 1986 was the highest. The incidence and the number of cases of Tiantai county was the highest in Taizhou city. From November to January of the next year was the main onset peak, and from April to June also had a small onset peak. The onset curve showed a double peak mode. The incidence number of age group of 20 to 49 accounted for 66.57 % and the ratio of the male to female was 2.58 ： 1. Farmers accounted for 80.95 % of all patients. The accordant rate of the suspected patients and the confirmed patients was 68.72 %, and the recessive infection rate of in healthy people was 3.13 %. The total density of small animal was 10.94 %, and the outdoor density was 13.07 % which was obviously higher than that in residential area 8.79 % （ P 〈 0.01 ）. Apodemus agrarius which accounted for 76.89 %. However, the dominant species of rodents at residential the distribution of specific group was 2 items and 16 kinds in all. The predominant species of rodents outdoors was Rattus norvegicus Berkenhout which accounted for 77.37 %. The virus carried rate of the Apodemus agrarius and R. norvegicus were 4.48 % and 3.95 % respectively. The virus carried rate of rodents were 0. 044 and 0. 036 respectively. The seasonal ebb and flow of the small animal density, the seasonal distribution of virus carried rate and the toxic index of rodents were by and large accord with the seasonal distribution of epidemi

关 键 词：肾综合征出血热 监测 发病率 带病毒率 

分 类 号：R373.32[医药卫生—病原生物学]