520例慢性乙型肝炎HBeAg阴性与阳性患者临床和HBV-DNA比较分析  

A Comparison of Clinical and HBV-DNA of 520 Cases of HBeAg-negative and HBeAg-positive Chronic Hepatitis B

作　　者：薛云平[1] 邬小萍[2] 温志立[1] 杨铁一[1] 袁小亮[3] 

机构地区：[1]南昌市第一医院感染科,南昌330008 [2]南昌大学第一附属医院感染科 [3]江西省胸科医院心内科,南昌330006

出　　处：《实用临床医学（江西）》2007年第8期25-27,共3页Practical Clinical Medicine

摘　　要：目的:了解HBeAg(-)慢性乙型肝炎(CHB)患者临床特点和血清HBV-DNA检测的意义。方法:对520例CHB患者的住院病历进行回顾性调查,分析HBeAg(-)和HBeAg(+)CHB患者HBV-DNA定量组内和组间差异。结果:HBeAg(-)CHB 166例,占31.92%;HBeAg(+)CHB 354例,占68.08%。HBeAg(+)组HBV-DNA总体上高于HBeAg(-)组;不同病程HBeAg(-)CHB比例轻度组为12.8%,中度组为13.2%,重度组为19.2%,重型组为31.4%,肝硬化组为47.5%。结论:目前我国CHB病例以HBeAg(+)者占多数,HBeAg(+)组HBV-DNA总体上高于HBeAg(-)组,随着病程进展HBeAg(-)CHB比例上升。Objective：To investigate the clinical characteristics and the implications of HBV DNA of HBeAg-negative and HBeAg-positive chronic hepatitis B （CHB）. Methods： A total of 520 hospitalized CHB cases were analyzed retrospectively. The serum HBV DNA level was analyzed by their serum HBeAg status. Results： Among the 520 cases, 166 （ 31.92% ） were HBeAg-negative and 354 （68.08%） were HBeAg-positive. Compared with HBeAg-positive group, HBeAg- negative group hadalower serum HBV DNA levels. There were 13（12.8%）, 27（19.2%）, 27 （13.2%）, 11（31.4%）, and 19（47. 5%） HBeAg-negative CHB cases in mild group（n=101）, middle group（n=204）, heavy group（n=140） , severe group （n=35）, and cirrhosis group（n= 40） respectively. Conclusion： HBeAg-positive CHB is still the predominant form of CHB in Chinese patients. HBeAg-positive group had a higher serum HBV DNA levels than HBeAg-negative group. The rate of HBeAg-negative CHB/total CHB rises with the development of process.

关 键 词：乙型肝炎 慢性 乙型肝炎病毒E抗原 乙型肝炎病毒DNA 

分 类 号：R512.62[医药卫生—内科学]