稀土酰基吡唑啉酮邻菲咯啉配合物的合成、表征及其生物活性  

Synthesis, Characterization and Biological Activity of Rare Earth Complexes with Acylpyrazolone and o-Phenanthroline

作　　者：何其庄[1] 马树芝[1] 许东芳[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《无机化学学报》2007年第10期1723-1728,共6页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.20671063);上海市科委纳米技术专项(No.0552nm036;No.0652nm046)资助项目

摘　　要：以稀土、邻菲咯啉、1-苯基-3-甲基-4-苯甲酰基-5-吡唑酮为原料在无水乙醇溶液中反应,制备了一类新型稀土三元配合物,通过元素分析、摩尔电导、基质辅助激光解析/电离质谱、1H核磁共振谱、红外光谱、拉曼光谱、紫外光谱、热重-差热分析及电子显微镜等手段对其进行了表征,确定了该配合物的化学组成:RE(PMBP)3Phen(RE=Sm3+,Eu3+,Y3+,Er3+,Gd3+),抗菌实验结果表明,稀土三元配合物对大肠杆菌、金黄色葡萄球菌和白色念珠菌有较强的抑制作用,抗菌谱广。通过MTT比色法对配合物诱导癌细胞凋亡能力做了初步研究,结果表明其具有较强的抑杀癌细胞的作用。New solid ternary complexes of rare earth with o-phenanthroline（Phen） and 1-Phenyl-3-methyl-4-benzoyl- 5-pyrazolone （HPMBP） were synthesized in ethanol solution. The complexes were characterized by elemental analysis,molar conductance, MALDI-MS, ^1H NMR, IR,Raman, UV-Vis,TG-DTA, TEM. The compositions of the complexes were confirmed to be RE（PMBP）3Phen （RE= Sm^3＋, Eu^3＋, Y^3＋, Er^3＋, Gd^3＋）. The antibacterial activities testing indicates that all these solid ternary complexes have antibacterial ability against Escherich coli,Staphy lococcus aureus, Candida albican. The antimicrobial spectrum of the complexes is broad. The cancer cells were withered by the complex as shown by MTT study.

关 键 词：配合物 抗菌 抗肿瘤 

分 类 号：O614.33[理学—无机化学] O641.4[理学—化学]