氯化水杨醛呋喃硫羰基腙合铜在家兔体内的药代动力学研究  

PHARMACOKINETICS OF THE NEW ANTIBIOTICS: COPPER SALICYLALDEHYDE 2 FURANTHIOCARBOXYHYDRAZONATE DICHLORIDE IN RABBITS

作　　者：葛蔚颖[1,2] 高允生[1,2] 刘丽娟[1,2] 李忠 朱玉云[1,2] 徐丽君[1,2] 

机构地区：[1]山东医科大学无机化学教研室 [2]泰山医学院药理学教研室

出　　处：《山东医科大学学报》1997年第1期72-75,共4页Acta Academiae Medicinae Shandong

摘　　要：用反相ＨＰＬＣ法研究了氯化水杨醛呋喃硫羰基腙合铜（ＣＳＦＴＣＨＤ）在家兔体内的药代动力学行为。实验结果表明，给家免静脉注射ＣＳＦＴＣＨＤ５ｍｇ／ｋｇ后的血清药时曲线符合二室开放模型；灌胃给药１０ｍｇ／ｋｇ后的血清药时曲线符合一室开放模型。静脉注射或灌胃给药均可达到有效抑菌浓度。The pharmacokinetics of a new antibiotics:copper salicylaldehyde 2 furanthiocarboxyhydrazonate dichloride was studied by reversed phase HPLC method after intravenous and intragastric administrations in rabbits.After 5 mg/kg intravenous administration,the curves of serum concentrations vs time were fit to a two compartment opened model and the mean of pharmacokinetic parameters were:T 1/2α =3.7min,T 1/2β =58.6min,V c=0.358 L/kg,K 12 =0.1255 min -1 ,K 10 =0.1278 min -1 ,K 21 =0.0248min -1 and AUC ic =160.3(min·μg)/ml.When the drug was administrated 10 mg/kg intragastriclly,the curves of serum concentrations vs time were fit to a one compartment model and the mean of pharmacokinetic parameters were:T 1/2ka =21.4min,T 1/2ke =81.6 min,T max =51.7min,C max =0.127μg/ml and AUC ig =40.7(min.μg)/ml,the absolute bioavailability to be corrected was 9.1%.

关 键 词：呋喃硫羰基腙 药代动力学 生物利用度 杀菌剂 

分 类 号：R969.1[医药卫生—药理学] R978[医药卫生—药学]