碳包铁纳米晶急性毒性实验及其对肝肾功能和血液系统的影响  

Acute toxicity of carbon-coated iron nanocrystal and its effect on liver and kidney functions and hematological system

作　　者：劳向明[1] 张海燕[2] 李锦清[1] 陈易明[2] 陈敏山[1] 元云飞[1] 张亚奇[1] 郑云[1] 

机构地区：[1]中山大学肿瘤防治中心肝胆科/华南肿瘤学国家重点实验室,广东广州510060 [2]广东工业大学材料与能源学院,广东广州510006

出　　处：《南方医科大学学报》2007年第10期1471-1475,共5页Journal of Southern Medical University

基　　金：国家自然科学基金(50372013);"十五"国家科技攻关计划(2003BA310A24);高等学校博士学科点专项科研基金(20050562002);广东省科技计划(2004B10301008);广东省医学科研基金(B2007068)~~

摘　　要：目的分析碳包铁纳米晶(CCIN)的急性毒性及其对肝肾功能和血液系统的影响。方法经小鼠尾静脉分别注入不同剂量的CCIN粒子,观察小鼠14d内的急性毒性反应;经大鼠尾静脉分别注入高、中、低剂量CCIN粒子及对照组注入生理盐水,分别于给药前1d,给药后第1、3、7、14天检测大鼠肝肾功能及血常规。结果小鼠静脉注射CCIN粒子的LD50=203.8mg/kg;当大鼠静脉注入CCIN 80mg/kg以内时,无动物死亡,肝肾功能、血液系统可能会有一过性轻微损害,但2周内一般可自行恢复。结论CCIN粒子毒性较低,在一定剂量范围内对肝肾功能及血液系统影响不大。Objective To study the acute toxicity of carbon-coated iron nanocrystal （CCIN） in mice and its effects on hepatic, renal and hematological functions. Methods Acute toxicity of CCIN was evaluated by observing the toxic reactions in mice within 14 days following intravenous injection of different doses of CCIN particles. The liver and kidney functions and blood chemistry were tested in rats before and at different time points after CCIN injection. Results The median lethal dose （LD50） of CCIN particles given by intravenous injection was 203.8 mg/kg in mice. Within the intravenous dose of 80 mg/kg injection, CCIN caused only mild alterations of the rats＇ biochemical and hematological indices that recovered without intervention in two weeks. Conclusion CCIN is characterized by low acute toxicity and mild side effects on the hepatic, renal and hematological functions within a certain dose range.

关 键 词：碳包铁纳米晶 急性毒性 肝功能 肾功能 血液系统 血清生化指标 

分 类 号：R318.08[医药卫生—生物医学工程]