窒息新生儿血中胰岛素样生长因子-1和表皮生长因子水平的变化及其临床意义  

The clinical significance of serum insulin-like growth factor-1 and epidermal growth factor in newborns with asphyxia

作　　者：李安琪[1] 冯晋兴[1] 郑义敏[1] 黄慧君[1] 王卫[1] 刘小红[1] 

机构地区：[1]深圳市儿童医院新生儿科,518026

出　　处：《中国小儿急救医学》2007年第5期388-389,共2页Chinese Pediatric Emergency Medicine

摘　　要：目的观察窒息新生儿血中胰岛素样生长因子(IGF)-1、表皮生长因子(EGF)的动态变化,探讨窒息对新生儿胃肠功能影响的可能机制。方法用放射免疫分析法动态测定48例窒息新生儿和30例正常足月新生儿出生后1、3、7d血中IGF-1、EGF的水平变化。观察窒息新生儿胃肠功能障碍的发生情况。结果轻、重度窒息组从生后第1天IGF-1水平较对照组明显降低,差异有非常显著性(P<0.01);第7天轻度窒息组IGF-1恢复至对照组水平(P>0.05),重度窒息组IGF-1仍较对照组低,差异有非常显著性(P<0.01)。轻度窒息组生后第3天EGF水平较对照组明显降低;重度窒息组在生后第1天EGF水平较对照组明显降低,差异有非常显著性(P<0.01);第7天轻、重度窒息组EGF水平恢复至对照组水平(P>0.05)。轻度窒息组有8例发生轻度胃肠功能障碍,重度窒息组有6例发生轻度胃肠功能障碍,3例发生中度胃肠功能障碍,3例发生重度胃肠功能障碍。结论窒息新生儿血中IGF-1、EGF水平的下降,可能是造成胃肠功能障碍的因素之一。Objective To observe the changes of serum insulin-like growth factor-1 （IGF-I） and epi- dermal growth factor（EGF） in newborns with asphyxia, and to investigate the mechanism of gastrointestinal disfunction. Methods The serum levels of IGF-1 and EGF of 48 newborns with asphyxia and 30 normal new- borns were determined on the first, third and seventh day after birth by using radioimmunoassay. The incidence of gastrointestinal disfunction in newborns with asphyxia was evaluated. Results The serum IGF-I levels of newborns with mild asphyxia were significandy lower than that of normal newborns on the first and third day after birth（ P 〈 0.01）, and recovered to normal level on the seventh day（ P 〉 0.05 ）. The serum IGF- 1 levels of newborns with severe asphyxia were significandy lower than that of normal newborns on the first, third and seventh day（P〈0.01）. The serum EGF-1 levels of newborns with mild asphyxia and severe asphyxia were sigrdficantly dereased than that of normal level from the third and first day respectively（ P 〈 0.01）, and recov- ered to normal level on the seventh day（ P 〈 0.05）. There were 8 of mild gastrointestinal disfunction in new- borns with mild asphyxia, while 6 of mild, 3 of moderate, and 3 of severe gastrointestinal disfunction in new- bores with severe asphyxia. Conclusion The decreases of the serum levels of IGF-1 and EGF in newborns with asphyxia might be involved in gastrointestinal disfunction.

关 键 词：窒息 胰岛素样生长因子-1 表皮生长因子 胃肠功能障碍 

分 类 号：R722.1[医药卫生—儿科]