胆固醇酯转运蛋白基因D442G多态性与维吾尔族自然长寿的关联  

The Correlation of the D442G Polymorphism of CETP Gene with the Natural Longevity in Uygur Population

作　　者：孙凌[1] 许群[2] 程祖亨[1] 邱长春[2] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054 [2]中国医学科学院基础医学研究所医学分子生物学国家重点实验室,北京100005

出　　处：《医学研究杂志》2007年第10期14-16,共3页Journal of Medical Research

基　　金：国家自然科学基金资助(批准号:30160089)

摘　　要：目的探讨胆固醇酯转运蛋白(CETP)基因D442G多态性与维吾尔族自然长寿之间的关系。方法以新疆和田地区191名90岁以上的维吾尔族自然长寿个体为研究对象,以53名在75岁前自然死亡的同地区、同民族相匹配个体作为对照。采用PCR-限制长度片段多态性(PCR-RFLP)和PCR-直接测序法(PCR-Sequencing)对CETP基因第15外显子D442G多态性进行分型。结果CETP基因D442G多态性基因型、等位基因分布在长寿组和对照组之间无差异。结论CETP基因D442G多态性与和田维吾尔族自然长寿无关。但D442G多态性分布不仅存在种族差异,在同一民族之间还存在地域差异。Objective To investigate the relationship between polymorphisms within the CETP gene, D442G,and natural longevity in the Uygur population. Methods 191 healthy individuals over 90 years old and 53 control individuals who died before their 75 years were recruited. The D442G polymorphism within CETP gene was genotyped by PCR - RFLP and PCR - Sequencing. Results There were no difference in the genotypes and alleles distribution of D442G polymorphisms within the CETP gene between longevity group and control group. Conclusions There were no the correlation between the D442G polymorphisms within CETP gene and natural longevity of Uygur population in Hetian. The difference of D442G polymorphism existed in not only races, but also regions where the same race dwelled.

关 键 词：胆固醇酯转运蛋白 基因D442G 多态性 维吾尔族 自然长寿 关联性 

分 类 号：Q987[生物学—遗传学]