超声评价糖尿病患者外周动脉病变与血管内皮舒张功能的关系  

Ultrasonic Evaluation on the Relationship between Peripheral Arterial Disease and Endothelial Dilation Function of Diabetic Patients

作　　者：张彩云[1] 冯卫[1] 

机构地区：[1]辽宁省沈阳市第一人民医院电诊科,沈阳110044

出　　处：《中国医药导刊》2007年第5期382-384,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:通过超声检测2型糖尿病患者胭动脉内膜-中层厚度(Intima-media Thickness,IMT),肱动脉内皮依赖性舒张功能,探讨其在2型糖尿病患者外周动脉病变中的早期诊断价值。方法:将2型糖尿病患者46例按照是否合并下肢血管病变分成二组,将正常对照组24例为一组,共分三组。应用彩色多普勒超声诊断仪分别测量各组的腘动脉IMT值以及血流介导的肱动脉内径扩张值(Flow-mediated Dilation,FMD),然后将各组指标对照分析。结果:糖尿病患者未出现下肢血管病变组与正常对照组比较,肱动脉FMD值明显降低,有显著性意义(P<0.01);FMD值与糖尿病患者的IMT值呈显著负相关,r=-0.745(P<0.05)。结论:超声可以通过测量肱动脉FMD值比IMT值更早出现改变,来说明糖尿病患者在合并下肢动脉病变之前,已存在血管内皮功能损害,而且,FMD值与IMT值呈显著负相关。Objective： To discuss the early value of popliteal artery intima - media thickness and brachial artery endothelium - dependent dilation measured with ultrasound in the diagnosis of peripheral arterial disease of type 2 diabetic patients. Methods： Forty - six type 2 diabetic patients were divided into two groups according to lower limb vascular complication and compared with normal controls twenty - four cases. IMT and flow mediated dilation （FMD） were detected by Colour Doppler Flow Imaging. Results： IMT of artery were increased and there were no significant differences （P 〈 0. 05 ） in diabetic patients without lower limb complication and normal controls, but FMD were significant decreased （P 〈 0.01 ）. Meanwhile, FMD was significant negative correlated with IMT（ r = - 0. 745, P 〈 0. 05 ）. Conclusion： FMD changed earier than IMT measured by Colour - Doppler Flow Imaging showed that the endothelium - dependent dilation lesions of type 2 diabetic patients have exsisted before lower limb complication, and FMD was negative correlation with IMT respectively.

关 键 词：超声检测 2型糖尿病 外周动脉病变 内膜中层厚度 内皮依赖性舒张功能 

分 类 号：R445.1[医药卫生—影像医学与核医学]