注射用复方氨苄西林钠的家兔体外抗菌实验  

Anti-infection effect of Compound Ampicillin Sodium for Injection in rabbits

作　　者：贺立泽[1] 王佩贤[1] 姚鸿萍[2] 曹永孝[2] 

机构地区：[1]广州安健实业发展有限公司,广东广州510420 [2]西安交通大学药学院,陕西西安710001

出　　处：《亚太传统医药》2007年第10期52-55,共4页Asia-Pacific Traditional Medicine

基　　金：陕西省卫生厅科研基金项目(04D30);注射用复方氨苄西林钠抗菌作用和药代动力学研究

摘　　要：目的:考察注射用复方氨苄西林钠的家兔体外抗菌特征。方法:体外抗菌考察单次和多次给家兔注射复方氨苄西林钠后,采集的家兔血浆对培养的金黄色葡萄球菌和大肠杆菌的抗菌作用。结果:与注射用氨苄西林钠组相比,注射用复方氨苄西林钠大、中、小剂量组增强了氨苄西林钠对金黄色葡萄球菌和大肠杆菌的抑菌作用(p<0.05或p<0.01)。结论:与注射用氨苄西林钠组相比,注射用复方氨苄西林钠可增强氨苄西林钠的抗菌作用。Objective： Test the antibiotics effect of Compound Ampicillin Sodium for Injection in rabbits. Methods： In vito, investigated Compound Ampicillin Sodium for Injection on antibiotics effect of staphylococcus and Escherichia coli after single and multiple dose administration with method of cup-plate method. Results： Compared with Arnpicillin Sodium for Injection, Compound Ampicillin Sodium for Injection 300mg· kg^-1 , 120mg · kg^-1 and 50 mg·kg^-1 could significantly increase the concentration of ampicillin sodium in plasma of rabbits （p〈0. 05 or p〈0. 01） and increase the effect of bactericide action on staphylococcus and Esch- erichia coli. Conclusion： Compared with Ampicillin Sodium for Injection, Compound Ampicillin Sodium for Injection could increase the anti-infection effect of ampicillin sodium.

关 键 词：注射用复方氨苄西林钠 注射用氨苄西林钠 抗菌作用 

分 类 号：R978.5[医药卫生—药品]