阿托伐他汀对充血性心力衰竭患者心功能C反应蛋白和vonWillebrand因子的影响  

Effect of atorvastatin on cardiac function,C-reactive protein and von Willebrand factor levels in patients with congestive heart failure

作　　者：刘亚林[1] 马景涛[1] 付华[1] 李星涛[1] 

机构地区：[1]河北医科大学第四医院心内科,河北省石家庄050011

出　　处：《中国基层医药》2007年第9期1473-1475,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨充血性心力衰竭(CHF)患者应用阿托伐他汀后对心功能和C反应蛋白(CRP)、von- Willebrand因子(vWF)的影响及意义。方法随机选择91例CHF患者,EF<0.35,46例加用阿托伐他汀,另外45例作为对照组。观察治疗前后心功能和CRP、vWF的变化。结果(1)用药前两组患者心功能和CRP、vWF水平差异无统计学意义(P>0.05);(2)加用阿托伐他汀的患者,心功能较对照组比较有明显改善(P<0.05);(3)用药后两组患者CRP、vWF水平均有明显降低(P<0.05),但外周血管阻力(SVR)无明显差异;(4)加用阿托伐他汀组的患者,其心率(HR)、CRP、vWF水平均较对照组治疗后有明显降低(P<0.05)。结论CHF患者加用阿托伐他汀可明显改善心功能,降低HR、血清CRP和vWF水平。Objective To investigate the effect of atorvastatin on cardiac function,C-reactive protein（CRP） and yon Willebrand factor（vWF） levels in patients with congestive heart failure（CHF）. Methods 91 patients with congestive heart failure were randomly included. Ejection fraction of patients was less than 0.35.46 patients received atorvastatin,and 45 patients were in control group. Cardiac function, CRP and vWF levels were compared between the two groups before and after treatment. Results （1）There was no significant difference in cardiac function, CRP and vWF in two groups before treatment（P〉0.05）. （2）Whereas there was a significant difference in cardiac function in patients received atorvastatin（ P〈0.05）. （3）There was a significant decrease in CRP and vWF levels in two groups（P 〈 0.05 ） after treatment, but SVR difference was not observed. （4）Besides, HR, CRP and vWF were significantly decreased in patients received atorvastatin compared to those of control group （ P 〈 0.05 ）. Conclusion Patients received atorvastatin could improve cardiac function and decrease HR and the levels of CRP and vWF.

关 键 词：心力衰竭 充血性 心功能 阿托伐他汀 C反应蛋白 VONWILLEBRAND因子 

分 类 号：R541.6[医药卫生—心血管疾病]