C反应蛋白与2型糖尿病合并脑梗死危险因素的相关性研究  

Association of high-sensitivity C-reactive protein with risk factors of cerebral infarction in patients with type 2 diabetic mellitus

作　　者：洪柳[1] 莫亚杰[1] 

机构地区：[1]广东省农垦中心医院神经内科,广东省湛江524002

出　　处：《中国基层医药》2007年第9期1498-1500,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨血清高敏C反应蛋白(hs-CRP)与2型糖尿病(DM)及合并脑梗死(DM+CI)的关系及与其他危险因素的关系。方法经CT和(或)MRI证实的脑梗死患者50例,2型糖尿病非脑梗死患者50例,健康对照组30例,检测其hs-CRP水平以及多项临床及生化指标并进行统计分析。结果血清hs-CRP在健康对照组[(0.73±0.46)mg/L]、DM组[(2.26±1.38)mg/L]及DM+CI组[(3.82±2.67)mg/L]三组间差异有统计学意义(P<0.05或P<0.01);hs-CRP与甘油三酯(TG)正相关(r=0.298,P<0.05),以hs-CRP为应变量的多元逐步回归分析表明TG、病程进入回归方程。结论DM患者CRP水平增加,合并CI的患者更明显,并与TG及病程有关,可能是2型糖尿病合并脑梗死的危险因素,CRP在DM发展为CI中起一定作用。Objective To examine the serum high-sensitivity C-reactive protein（hs-CRP） levels in subjects with type 2 diabetic mellitus （DM） or DM accompanied by cerebral infarction （DM ＋ CI）, and the relationship between the serum high-sensitivity C-reactive protein（hs-CRP） levels, and to investigate risk factors of cerebral infarction in patients with type 2 diabetic mellitus. Methods The serum high-sensitivity C-reactive protein（hs-CRP） levels were measured in 50 DM patients, 50 DM ＋ CI patzents and 30 healthy controls by ultra-sensitive immunoassay. hs-CRP values and its relationship with cerebral infarction in patients with type 2 diabetic mellitus and other factors, such as age, BMI, TG, etc, were analyzed. Results Univariate analysis revealed significant differences in hs-CRP concentrations between controls [ （ 0.73 ±0.46 ） mg/L] and subjects with DM [ （2.26 ±1.38 ） mg/L], or subjects with DM ＋ CI[ （3.82 ±2.67 ）mg/L] （ P （ 0.05 or P （ 0.01 ） ; correlation analysis results suggested that the serum high-sensitivity C-reactive protein（hs-CRP） levels were related to triglyceridemia（TG） （ P （ 0.05 ）, multiple regression analysis revealed C-reactive protein significantly and TG,or duration. Conclusions C-reactive protein is related to the increase with durations of type 2 diabetic mellitus and with TG of the patients, and may contribute to development to cerebral infarction from type 2 diabetic mellitus.

关 键 词：C反应蛋白 糖尿病 非胰岛素依赖型 脑梗死 危险因素 

分 类 号：R587.1[医药卫生—内分泌]