胃肠舒片的药理与毒理实验研究  

The Pharmacological and Toxicological Experimenal Research of Weichangshu Tablet

作　　者：刘孟安[1] 赵岩[1] 张树平[1] 孙丰润[1] 姜学连[1] 

机构地区：[1]滨州医学院烟台校区,山东烟台264003

出　　处：《时珍国医国药》2007年第10期2460-2461,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察胃肠舒片对胃肠运动的影响及毒副作用。方法胃肠舒片对胃肠推进运动实验,将动物随机分组,对比观察分析;对动物离体平滑肌的影响,采用给药前后对比观察分析;急性毒性实验将动物随机分组,对比观察;给予不同浓度胃肠舒片溶液灌胃,实验数据进行统计学处理(t检验)。结果胃肠舒片对胃肠运动有明显的推进作用,其机理与增强胃肠平滑肌自发活动的收缩幅度有关;口服给药安全,无明显毒副作用。结论胃肠舒片是理想的纯中药制剂的胃肠动力药。Objective To observe Weichangshu Tablet＇s effect on gastroentero -movement and the toxic side effect. Methods The experiment of Weichangshu Tablet＇s effect on gastroentero - propelling movement was clone by dividing the animals into groups at random ,observing and analyzing contrastively. The experiment of WeichAngshu Tablet~ effect on animal unorganized ileum leiomyo was clone by observing and analyzing between before medicine and after medicine. The acute toxicity experiment was clone by dividing the animals into groups at random in which the animals were given different concentration solution of Weichangshu Tablet by way of gastric perfusion. Results Weichangshu Tablet promoted gastroentero - movement. Its mechanism is related to its building up the con- tractive range of the spontaneous activity of gastroentero - Leiomyo. Oral taking medicine is safe, and there is no evident toxicity side effect. Conclusion Weichangshu Tablet is a kind of perfect gastroentero - dynamic medicine of pure Chinese herb preparation.

关 键 词：胃肠舒片 吗丁啉 胃肠平滑肌 药理作用 毒理学 

分 类 号：R285.5[医药卫生—中药学]