罗格列酮对合并空腹血糖正常代谢综合征的急性冠脉综合征患者部分炎症因子的影响  

Influence of rosiglitazone on inflammatory indexes in patients with acute coronary syndrome and metabolic syndrome followed normal fasting blood glucose

作　　者：林斌[1] 陈丽捷[1] 章耀[1] 王军[1] 曾向村[1] 

机构地区：[1]温州市第二人民医院心内科,浙江温州325000

出　　处：《心血管康复医学杂志》2007年第5期504-507,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探讨罗格列酮对空腹血糖正常的代谢综合征（MS）的急性冠脉综合征（ACS）患者体内部分炎症水平的影响。方法：30例合并空腹血糖正常的MS的ACS患者,随机被分为对照组（A组,按常规治疗）和罗格列酮组（B组,常规治疗＋罗格列酮治疗）,疗程均为4周。治疗前、后分别测定空腹血糖,血清总胆固醇（TC）,低密度脂蛋白-胆固醇（LDL-C）,高敏C反应蛋白（hs-CRP）,肿瘤坏死因子α（TNF-α）和白介素6（IL-6）水平。结果：治疗4周后,治疗组空腹血糖,空腹胰岛素,血清hs-CRP、TNF-α水平均明显降低（P〈0.05-〈0.01）,且较对照组更显著（P〈0.05-〈0.01）。结论：罗格列酮可减少粥样硬化斑块炎症反应,使合并空腹血糖正常的代谢综合征的急性冠脉综合征患者受益。Objective： To evaluate the therapeutic efficacy on inflammatory indexes in patients with acute coronary syndrome （ACS） and metabolic syndrome （MS） followed normal fasting blood glucose. Methods; A total of 30 ACS patients with MS followed normal fasting blood glucose were divided into two groups randomly; control group （group A, received routine therapy） and rosiglitazone therapy group （group B, received rosiglitazone 4rag daily on routine therapy）. Therapeutic course was 4 weeks. The serum levels of fasting blood glucose （FBG）. total cholesterol （TC）. low density lipoprotein-cholesterol （LDL-C） and high sensitive C-reactive protein （hs-CRP）. tumor necrosis factor （TNF） -α, interlendin （IL） -6 were detected before and after therapy. Results： Four weeks later, the levels of FBG, FINS, IR, hs-CRP and TNF-α decreased significantly and more than those of control group （P〈0.05-〈0.01）. Conclusion. Rosiglitazone can decrease inflammatory reaction in patients with metabolic syndrome followed normal fasting blood glucose.

关 键 词：罗格列酮 冠状动脉疾病 代谢综合征 炎症 

分 类 号：R541.4[医药卫生—心血管疾病]