枯草芽孢杆菌JA-206对皮肤癣菌抑制作用的研究  

The Study of Antagonism of Bacillus subtilis JA-206 against Dermatophytes

作　　者：吕树娟[1] 方海红[1] 刘静[2] 王明丽[1] 

机构地区：[1]安徽医科大学微生物学教研室,安徽合肥230032 [2]中国科学院离子束生物工程学重点实验室,安徽合肥230031

出　　处：《激光生物学报》2007年第5期636-639,共4页Acta Laser Biology Sinica

摘　　要：低能离子诱变筛选获得的枯草芽孢杆菌JA-206的发酵粗提液对红色毛癣菌和须毛癣菌有较强的抑菌或杀菌作用,粗提液经高温、蛋白酶处理后仍然有较高的稳定性,将JA-206粗提液经多步分离纯化,得到三种单一纯化产物抗菌肽AFP1、AFP2和AFP3,其中AFP1和AFP3对两种皮肤癣菌显示出明显的抑菌或杀菌作用。The fermentation crude extract of Bacillus subtilis JA-206 screened by the technology of ion implantation can effectively inhibit or kill T. purpureatum and T. mentagrophytes. The crude extract is stable against heat and enzyme. Three types of antimicrobial peptides, named AFP1 ,AFP2and AFP3 were purified from the crude extract of Bacillus subtilis JA-206. AFP1 and AHP3 both had strong inhibitory activity against two kind of dermatophytes.

关 键 词：枯草芽孢杆菌JA-206 抗菌肽 红色毛癣菌 须毛癣菌 

分 类 号：Q939.93[生物学—微生物学]