ATM基因与AT细胞辐射敏感性的研究进展  

Advances in research on radiosensitivity of AT cells and AT mutated gene

作　　者：史芳[1] 王芳 

机构地区：[1]天津医学高等专科学校医学遗传学教研室,300222 [2]天津市血液学研究所血液病医院检测中心,300020

出　　处：《国际放射医学核医学杂志》2007年第4期248-250,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：共济失调性毛细血管扩张（AT）是由突变型AT（ATM）基因所引起，其突出特点是AT细胞辐射高敏感性。AT临床症状、ATM基因的定位、结构与功能已基本明确，近年来人们对ATM基因突变与AT细胞辐射敏感性的相关性研究已引起广泛重视，使其成为研究辐射增敏的一个重要的契入点。Ataxia-telangiectasia （AT） is caused by the mutation of AT （ATM）mutated gene and it is characterized by high radiosensitivity of AT cells. Progress in the research of AT is reviewed in this paper, including the clinical symptoms of this disorder, as well as the localization , structure and function of ATM gene, and summarized the studies on the gene mutation and high radiosensitivity of AT cells in recent years. Further study to ATM gene may provide an important entrance for radiosensitivity-related therapy.

关 键 词：共济失调性毛细血管扩张 基因 ATM 辐射耐受性 基因表达调控 

分 类 号：R54[医药卫生—心血管疾病]