2-氯甲基-4-乙氧基吡啶盐酸盐的合成  

Synthesis of 2-Chloromethyl -4-ethoxylpyridine Hydrochloride

作　　者：任旭红[1] 王庆河[1] 邓明 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]东北制药集团有限责任公司,辽宁沈阳110026

出　　处：《精细化工中间体》2007年第5期27-28,36,共3页Fine Chemical Intermediates

摘　　要：以2-甲基吡啶为起始原料,经N-氧化、硝化、乙氧基取代、酰化、水解、卤代等步骤,合成了2-氯甲基-4-乙氧基吡啶盐酸盐1,5步总收率为20%。2-Chloromethyl-4-ethoxylpyridine hydrochloridel was synthesized starting from 2-methylpyridine through N-oxidation,nitration,ethoxylation,acylation,hydrolysis and halogenation to give 2-hydroxymethyl-4-ethoxylpyridine and was chlorinated by sulforous oxychloride and followed by salf formation which an overall yield of 20%, indicating that the method was suitable to industrialization because of simple operation, available raw materials and low cost.

关 键 词：2-氯甲基-4-乙氧基吡啶盐酸盐 中间体 合成 

分 类 号：TQ225.2[化学工程—有机化工]