脑梗死患者治疗前后血清IL-2、IL-6和VEGF检测的临床意义  

Clinical Significance of Determination of Changes of Serum IL-2,IL-6 and VEGF Levels After Treatment in Patients with Cerebral Infarction

作　　者：施洪超[1] 王军[1] 姜建东[1] 

机构地区：[1]南京医科大学附属南京第一医院神经内科,210006

出　　处：《放射免疫学杂志》2007年第5期390-391,共2页Journal of Radioimmanology

摘　　要：目的:探讨32名脑梗死患者治疗前后血清IL-2、IL-6和VEGF水平的变化及意义。方法:分别应用放射免疫分析和ELISA对32例脑梗死患者进行了血清IL-2、IL-6和VEGF水平的测定,并与35名正常健康人做比较。结果:在治疗前血清IL-6、VEGF水平非常显著地高于正常人组(P<0.01),而IL-2水平则显著地低于正常人组(P<0.01)。经治疗后3个月与正常人比较,仍有显著差异(P<0.05)。结论:脑梗死的发生、发展与血清IL-2、IL-6和VEGF水平密切相关。Objective To investigate the clinical significance of changes of serum IL-2, IL-6 and VEGF levels after treatment in patients with cerebral infarction. Methods Serum IL- 2, IL- 6 levels were determined with RIA and VEGF levels detected with ELISA in 32 patients with cerebral infarction both before and after treatment, as well as in 35 controls. Results Before treatment, the serum IL-6, VEGF levels in the patients were significantly higher than those in the controls （P〈0.01）, while the serum IL-2 levels were significantly lower （P 〈 0.01 ）. After 3 months＇ treatment the levels, though corrected markedly, remained significantly different from those in controls （P 〈 0.05）. Conclusion Changes of serum IL - 2, IL - 6 and VEGF levels might be of prognostic val- ues in patients with cerebral infarction.

关 键 词：脑梗死 白细胞介素-2 白细胞介素-6 血管内皮生长因子 

分 类 号：R581.1[医药卫生—内分泌]