培哚普利与胺碘酮治疗阵发性心房颤动的2年随机对照研究  

A two-year randomized controlled trial of perindopril and amiodarone in patients with paroxysmal atrial fibrillation

作　　者：黄震华[1] 朱雅琴[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2007年第10期730-733,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:观察培哚普利治疗阵发性心房颤动的疗效。方法:71例阵发性心房颤动病人随机分为治疗组和对照组。治疗组35例,每日口服培哚普利4mg,氢氯噻嗪12.5mg,对照组36例,每日口服胺碘酮0.2g,共治疗2a。结果:治疗组5例、对照组4例发生持续性心房颤动(P>0.05)。治疗组和对照组各2例发生缺血性脑卒中(P>0.05)。2组阵发性心房颤动发作次数均有减少,培哚普利联合氢氯噻嗪治疗尚有抑制心房重构的作用。结论:培哚普利联合小剂量利尿剂可减少阵发性心房颤动的发作。AIM： To observe the efficacy of perindopril in the treatment of paroxysmal atrial fibrillation. METHODS： Seventy-one paroxysmal atrial fibrillation patients were randomized into the treatment group （n = 35） and control group （n = 36）. The patients in the treatment group received perindopril 4 mg and dihydrochlorothiazide 12.5 mg orally per day. The patients in the control group received amiodarone 0.2 g orally per day. The treatment periods were 2 years. RESULTS： Five patients in the treatment group and 4 patients in the control group progressed into persistent atrial fibrillation （P 〉 0.05） . Two patients in both group occurred ischemic stroke （P 〉 0.05）. The occurrence of atrial fibrillation decreased in both group. The atrial remodeling was prevented in the treatment group. CONCLUSION： Perindopril and small doses of diuretics may decrease the occurrence of paroxysmal atrial fibrillation.

关 键 词：心房颤动 培哚普利 胺碘酮 

分 类 号：R541.7[医药卫生—心血管疾病]