伐昔洛韦缓释片体外释放速率与人体内吸收速率的相关性  

Correlation between dissolution rate in vitro and absorption rate in vivo of valaciclovir sustained release tablets

作　　者：许小红[1] 李铜铃[2] 陈束叶[2] 

机构地区：[1]成都医学院药学系,四川成都610083 [2]四川大学华西药学院,四川成都610041

出　　处：《中国新药与临床杂志》2007年第10期759-761,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:研究伐昔洛韦缓释片体外释放速率与人体内吸收速率的相关性。方法:以水为释放介质,测定伐昔洛韦缓释片的体外释放速率;采用Wagner-Nelson法计算单剂量口服缓释片后体内吸收分数,考察吸收相体内吸收与体外释放的相关性。结果:伐昔洛韦缓释片体内吸收分数(f_a)与体外释放速率(f_r)的关系为:f_a=2.11f_r -20.12,r=0.994 0(n=5)。结论:伐昔洛韦缓释片人体内外相关性良好(P<0.001)。AIM： To explore the in vivo-in vitro correlation of valaciclovir sustained release tablets （VSRT） . METHODS： In vitro release rate of VSRT was studied by the Chp basket method using the following conditions： in 900 ml of water at （37.5 ± 0.5） ℃ at a rotation speed of 100 rpm. In vivo bioavailability was tested in twenty healthy male volunteers and the fractions absorbed were calculated by Wagner-nelson method. RESULTS： The relationship between the release fraction （fr） and the absorption fraction （fa） was： fa =2.11 fr - 20.12, r = 0.994 0 （n = 5） . CONCLUSION： There is a good correlationship of VSRT between dissolution rate in vitro and absorption rate in vivo.

关 键 词：伐昔洛韦 片剂 迟效制剂 体内外相关 Wagner-Nelson法 

分 类 号：R943.4[医药卫生—药剂学]