氯氮平在家兔体内死后再分布规律研究  

Study of postmortem redistribution of clozapine in rabbit

作　　者：王琦玮[1] 周海梅[2] 李朴[2] 马锦琦[2] 莫耀南[2] 刘良[1] 

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]河南科技大学法医学系,河南洛阳471003

出　　处：《中国法医学杂志》2007年第4期223-225,共3页Chinese Journal of Forensic Medicine

摘　　要：目的阐明死后48h内家兔体内氯氮平再分布规律,为相关法医鉴定工作提供借鉴。方法取家兔15只,随机分为5组,以氯氮平灌胃,分别于死后0、6、12、24、48h取心血、外周静脉血、尿液、肝组织检测氯氮平浓度。结果家兔死亡后心血、外周静脉血、肝脏氯氮平浓度不断升高,尿液氯氮平浓度不断降低;死后早期浓度变化率大于晚期浓度变化率。死后48h心血、外周静脉血、肝脏、尿液氯氮平浓度分别为死后0h各检材氯氮平浓度的418%、193%、154%和29%。结论死亡一段时间后,提取生物检材,检测出的氯氮平浓度并不能准确反映刚死时的实际浓度。Objective Illuminate postmortem redistribution rule of clozapine in 48h after death in rabbit, and offer some clue for forensic identification. Methods Fifteen rabbits were distribute into five groups randomly, and elozapine was infused into stomach. Samples including cardiac blood, peripheral vein blood, urine and liver were collected at Oh, 6h, 12h, 24h, 48h after death, respectively, then the concentration of clozapine was detected in these tissues. Results Clozapine concentrations of cardiac blood, peripheral vein blood and liver rise constantly, contrarily, clozapine concentration of urine descent in rabbits after death. In addition, ratios of concentration change of clozapine are larger at early phase than later phase. Clozapine concentrations of cardiac blood, peripheral vein blood, liver and urine at 48h after death are 418%, 193%, 154%, 29% of concentrations at Oh after death, respectively. Conclusion Clozapine concentrations of tissues collected after death do not reflect the actual concentrations at time of death.

关 键 词：法医毒理学 死后再分布 氯氮平 

分 类 号：D919[医药卫生—法医学]