冠心病患者血清C反应蛋白和可溶性细胞间粘附分子1与肺炎衣原体感染的相关性  

Study on the Relationship Between Serum Levels of C-Reactive Proteion and Soluble Intercellular Adhesion Molecule-1 and the Infection of Chlamydia Pneumoniae in Patients with Coronary Heart Disease

作　　者：成士清[1] 刘成玉[2] 徐守伟[1] 刘冰冰[1] 

机构地区：[1]山东省立医院检验科,山东省济南市250021 [2]青岛大学医学院诊断学教研室,山东省青岛市266021

出　　处：《中国动脉硬化杂志》2007年第6期448-450,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨冠心病患者血清炎症标志物C反应蛋白和可溶性细胞间粘附分子1水平的变化及其与肺炎衣原体感染的关系。方法采用酶联免疫吸附法检测60例急性心肌梗死、不稳定型心绞痛、陈旧性心肌梗死、稳定型心绞痛及40例对照者血清C反应蛋白、可溶性细胞间粘附分子1及肺炎衣原体抗体IgG、IgM。结果冠心病组肺炎衣原体IgG阳性率和浓度均高于对照组(P<0.01),冠心病各组之间肺炎衣原体IgG和IgM阳性率差异无显著性(P>0.05),急性心肌梗死组肺炎衣原体IgG浓度高于陈旧性心肌梗死组、不稳定型心绞痛组和稳定型心绞痛组(P<0.05);冠心病组C反应蛋白、可溶性细胞间粘附分子1水平高于对照组(P<0.01),急性心肌梗死组C反应蛋白、可溶性细胞间粘附分子1水平高于不稳定型心绞痛组、陈旧性心肌梗死组和稳定型心绞痛组(P<0.01),不稳定型心绞痛组C反应蛋白、可溶性细胞间粘附分子1水平高于稳定型心绞痛组(P<0.05);肺炎衣原体IgG浓度、C反应蛋白、可溶性细胞间粘附分子1之间有很好的相关性(P<0.05)。结论炎症标志物水平变化在一定程度上反映了冠心病患者病情变化,肺炎衣原体感染与冠心病有关,炎症、感染可能共同参与了冠心病的发生发展。Aim To explore the relation between serum levels of C-reactive protein（CRP） and soluble intercellular adhesion molecule-1（sICAM-1） and Chlamydia pneumoniae（Cpn） infection and coronary heart disease（CHD）.Methods Serum levels of CRP,sICAM-1 and IgG,IgM antibodies to Cpn were detected by enzyme-lined immunosorbent assay（ELISA） in 60 patients with CHD and 40 healthy subjects.These patients were divided into four groups：acute myocardial infarction（AMI）,unstable angina pectoris（UAP）,old myocardial infarction（OMI） and stable angina pectoris（SAP）.Results Cpn-IgG positive rates and levels in patients with CHD were significantly elevated compared with control group（P〈0.01）;Cpn-IgG positive rates between each group weren＇t different significantly（P〉0.05）;Cpn-IgG levels in AMI were higher than in OMI,UAP and SAP（P〈0.05）;Cpn-IgM positive rates in patients with CHD weren＇t different compared with control group（P〉0.05）.The levels of CRP and sICAM-1 in patients with CHD were significantly elevated compared with control group（P〈0.01）;the levels of CRP and sICAM-1 in AMI were significantly higher than in UAP,OMI and SAP（P〈0.01）;The levels of CRP and sICAM-1 in UAP were higher than in SAP.There was correlation between the levels of CRP,sICAM-1 and Cpn-IgG in patients with CHD（P〈0.05）.Conclusion The levels of CRP and sICAM-1 may reflect the severity of CHD at some degree.There is correlation between Chlamydia pneumoniae infection and CHD.Both inflammation and infection are revelant to CHD.

关 键 词：临床诊断学 冠心病 C反应蛋白 可溶性细胞间粘附分子1 肺炎衣原体 

分 类 号：R44[医药卫生—诊断学]