青蒿素类衍生物抗炎免疫抑制活性研究进展  

The anti-inflammatory and immunosuppressive activity of artemisinin derivatives

作　　者：王峻霞[1] 唐炜[1] 左建平[1] 

机构地区：[1]中国科学院上海药物研究所新药研究国家重点实验室免疫药理室,上海201203

出　　处：《国际药学研究杂志》2007年第5期336-340,共5页Journal of International Pharmaceutical Research

基　　金：中科院知识创新项目资助课题(NoKSCX2-SW-202);上海市科学技术委员会科研计划项目资助课题(No06DZ19006)

摘　　要：青蒿素类衍生物具有抗炎和免疫抑制活性。临床研究结果表明,青蒿素类衍生物对各类红斑狼疮、皮炎及关节炎有效;研究表明,青蒿素类衍生物在多种疾病动物模型上具有抗炎和免疫抑制活性。为了研究和获得免疫抑制活性更高的化合物,一系列经过结构改造后合成的新型青蒿素类化合物相继被报道。但到目前为止,有关青蒿素类衍生物免疫抑制活性的作用机制尚不清楚。本文主要综述了近年来青蒿素类衍生物抗炎和免疫抑制药理作用及其作用机制的研究进展。Artemisinin and its derivatives exhibit potent anti-inflammatory and immunosuppressive activity. In clinical investigations, they were used for the treatment of systemic lupus erythematosus （ SLE ）, dermatitis and rheumatic arthritis （RA） with promising results. In laboratory studies, they showed anti- inflammatory and immunosuppressive effect on various animal disease models. Recently, a series of new artemisinin derivatives have been synthesized to develop potent immunosuppressive agents. However, the underlying mechanisms mediating their anti-inflammatory and immunosuppressive effects are still unknown. Here, we introduce the anti-inflammatory and immunosuppressive effect of artemisinin and its derivatives, and discuss their possible mechanisms based on the recent studies in literature.

关 键 词：青蒿素 青蒿素类衍生物 抗炎 免疫抑制 

分 类 号：R285[医药卫生—中药学]