系统性红斑狼疮患者外周血T淋巴细胞亚群的变化  

The Change of Peripheral Blood T Lymphocyte Subsets in Patients with Different Clinical Types of Systemic Lupus Erythematosus

作　　者：许坤[1] 张永亮[1] 张敬然[1] 

机构地区：[1]解放军第251医院,河北张家口075000

出　　处：《实用医技杂志》2007年第29期3991-3992,共2页Journal of Practical Medical Techniques

摘　　要：目的:研究系统性红斑狼疮(SLE)患者外周血T淋巴细胞亚群变化及其临床意义。方法:对30例患者和20例健康者,采用特异性荧光抗体标记,流式细胞检测T淋巴细胞亚群的变化。结果:SLE活动组CD4+细胞数明显降低(P<0.05);CD4+/CD8+比值明显降低(P<0.05)。结论:T淋巴细胞亚群在SLE的发病机制中起重要作用。Objective To study the change of T lymhocyte subsets with systemic lupus erythematosus. Methods 30 patients with systemic lupus erythematosus and 20 cases of healthy subjects were investigated and the change of T Lymphocyte subsets were counted by flow cytometer. Results Decrease in CD4^＋ cells and was observed in SLE patients（P 〈 0.05 ）, Conclusion T lymphocyte isplay an important role in the development of SLE.

关 键 词：系统性红斑狼疮 T淋巴细胞亚群 流式细胞术 

分 类 号：R593.241[医药卫生—内科学]