白芍总苷对膝骨性关节炎患者血清一氧化氮和白细胞介素-1β水平的影响  

Effects of total glucosides of paeonia on the serum levels of NO and IL-1β in patients with knee osteoarthritis

作　　者：于慧敏[1] 聂英坤[1] 王璟璐[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院中医科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2007年第5期455-456,459,共3页Journal of Harbin Medical University

摘　　要：目的探讨白芍总苷对膝骨性关节炎(OA)患者血清一氧化氮(NO)和白细胞介素-1β(IL-1β)水平的影响。方法60例膝OA患者随机分成两组,分别给予白芍总苷和对乙酰氨基酚治疗组(A组)、单纯对乙酰氨基酚治疗组(B组)。测量患者在用药前及用药4周后血清的NO、IL-1β水平。结果用药4周后,两组NO和IL-1β的水平都有所下降,但白芍总苷治疗组NO和IL-1β下降较明显(P<0.05),有统计学意义。结论白芍总苷能有效辅助改善膝OA患者的临床表现,降低NO和IL-1β的水平。Objective To explore the effect of total glucosides of paeonia（TGP） on the serum levels of NO and IL-1β in patients with knee osteoarthritis（OA）. Methods Sixty cases of osteoarthritis were divided into two groups randomly. Group A was given TGP combined acetaminophen, group B was given acetaminophen. Four weeks later, the levels of NO and IL-1β in serum were detected. Results The NO and IL-1β levels of TGP-treated patients were obviously lower than that of patients with acetaminophen. Conclusion TGP can decrease the serum NO and IL-1β levels,and improve symptoms of OA patients.

关 键 词：骨性关节炎 白芍总苷 一氧化氮 白细胞介素-1Β 

分 类 号：R684.3[医药卫生—骨科学]