脂联素受体2基因在饮食诱导肥胖大鼠肝脏组织中的表达  

Expression of Adiponectin Receptor 2 in Diet-Induced Obese Rat′s Liver

作　　者：朱永生[1] 刘峰[2] 郭锡镕[2] 

机构地区：[1]南京医科大学第二附属医院儿童医学中心,南京210011 [2]南京医科大学儿科研究所,南京210029

出　　处：《实用儿科临床杂志》2007年第19期1479-1480,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨脂联素受体2(AdipoR2)基因在饮食诱导肥胖大鼠模型肝脏中的表达差异。方法采用反转录PCR(RT-PCR)法检测饮食诱导肥胖与正常组大鼠肝脏中的AdipoR2表达差异,探讨其与大鼠胰岛素敏感性、血糖的关系。结果饮食诱导肥胖大鼠AdipoR2表达明显高于正常组,同时肥胖大鼠血糖明显高于正常组,胰岛素敏感性明显低于正常组。结论高能量饮食能刺激大鼠肝脏组织AdipoR2表达。Objective To investigate the different expressions of adiponcctin receptor 2（AdipoR2） mRNA in liver between diet - induced obese rats and controls. Methods The level of AdipoR2 mRNA expression was detected by reverse transcriptase polymerase chain reaction （RT- PCR）. Insulin sensitivity was evaluated by insulin sensitivity index（ISI）. Results Diet -induced obese rats showed higher expression of AdipoR2 mRNA compare to controls. The ISI of diet - induced obese rats was lower than that of controls. Conclusion High energy diet induceds AdipoR2 expression in liver.

关 键 词：脂联素受体2 肥胖 胰岛素敏感性 大鼠 

分 类 号：R723.14[医药卫生—儿科]