糖尿病多发家系红细胞胰岛素降解酶活性的研究  

INSULIN DEGRADING ENZYME ACTIVITY OF ERYTHROCYTES IN MULTIPLEX DIABETIC PEDIGREES

作　　者：李晨钟[1] 张素华[1] 邱鸿鑫[1] 王鼎年 余路[1] 粟绍初[1] 李萍[1] 吴应珍[1] 

机构地区：[1]重庆医科大学附一院内一科

出　　处：《中华内分泌代谢杂志》1997年第2期81-85,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：为了探讨红细胞胰岛素降解酶活性（ＥＩＤＥＡ）作为ＮＩＤＤＭ遗传分析指标的可能性，采用放射酶分析法检测了家族性ＮＩＤＤＭ患者４５例及其无糖尿病的一级亲属５１例，无家族史的ＮＩＤＤＭ患者５３例及６５例正常人的ＥＩＤＥＡ。同时检测了空腹血浆胰岛素（ＦＩＮＳ），并对部分个体作胰岛素释放试验。结果表明，在家系、非家系ＮＩＤＤＭ患者中，ＥＩＤＥＡ及ＦＩＮＳ高于正常人，而且这二个指标呈负相关。一级亲属中，年龄≥４５岁，体重指数≥２４ｋｇ／ｍ２的亚组的ＥＩＤＥＡ和ＦＩＮＳ高于正常人相应亚组。接受口服葡萄糖负荷的各组，其ＥＩＤＥＡ与血浆胰岛素在各时相均呈负相关。我们认为：①ＮＩＤＤＭ患者的ＥＩＤＥＡ升高，提示胰岛素降解加速；②中年以上、肥胖的非糖尿病一级亲属的胰岛素敏感性低于正常人；③ＥＩＤＥＡ可以作为ＮＩＤＤＭ遗传分析的指标。To investigate the possibility of using insulin degrading enzyme activity of erythrocytes (EIDEA)as one of inherited markers of NIDDM, EIDEA was determined with the method of radioassay of enzyme activity in 45 multiplex diabetic patients (with 3 or more NIDDM patients in the family) and their 45 nondiabetic first_degree relatives, 53 NIDDM patients without family history of diabetes, and 65 healthy subjects. Fasting plasma insulin (FINS) was also determined in all subjects. Moreover, we conducted an insulin releasing test on some subjects. The results showed that EIDEA and FINS were increased in both groups of diabetic subjects either with or without family history as compared with the healthy subjects. Moreover, EIDEA was inversely correlated with FINS in two groups of diabetic patients. In the subgroup of first_degree relative with age≥45yr and BMI≥24kg/m 2, EIDEA and FINS were higher than the corresponding values in the healthy subgroup. In all the groups receiving oral glucose load, EIDEA was inversely correlated with plasma insulin at all stages. We consider that ①the rate of insulin degradation in erythrocytes is increased in NIDDM patients; ②the insulin sensitivity of the middle_aged and obese nondiabetic first_degree relatives is lowered as compared with the controls; ③EIDEA can be used as one of inherited markers of NIDDM.

关 键 词：糖尿病 胰岛素降解酶 遗传标志 NIDDM 家系 

分 类 号：R587.102[医药卫生—内分泌]