NIDDM 患者转铁蛋白尿和慢性并发症的关系  

RELATIONSHIP BETWEEN TRANSFERRINURIA AND CHRONIC COMPLICATIONS IN PATIENTS WITH NIDDM

作　　者：徐一甄[1,2] 史虹莉[1,2] 沈稚舟[1,2] 叶山东[1,2] 朱禧星[1,2] 张桂生[1,2] 刘国明[1,2] 徐振华[1,2] 

机构地区：[1]上海医科大学华山医院糖尿病研究室 [2]上海第二医科大学科技中心实验室

出　　处：《中华内分泌代谢杂志》1997年第2期101-103,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：将７０例ＮＩＤＤＭ患者分成高转铁蛋白尿组和正常转铁蛋白尿组（每组３５例），比较两组的并发症发生情况。结果：两组血糖控制情况基本相同；高转铁蛋白尿组年龄较大、病程较长、体重指数较大，血压较高、尿微量白蛋白排泄率明显增加，且与微量转铁蛋白尿指数呈正相关，心脏植物神经功能异常程度和眼底病变发生率也较严重，胰岛素浓度和Ｌｐ（ａ）水平也明显升高。提示转铁蛋白尿是糖尿病慢性并发症的信号。According to the Transferrin/Creatinine (TRF/Cr)level, 70 NIDDM patients were divided into two groups, i.e., high TRF/Cr group and normal TRF/Cr group, 35 cases for each. Incidence of complications was compared between the two groups. The results showed that basically comparable control of blood sugar was reached in the two groups. It was found that the age of the patients, the course of diabetes, BMI and blood pressure were greater in high TRF/Cr group than those in normal TRF/Cr group. In high TRF/Cr group, there was an increase of urinary albumin excretion, and there was also a positive correlationship between urinary albumin excretion rate and transferrin excretion rate. Besides, the degree of cardiac autonomic neuropathy was severer, and the number of cases with diabetic retinopathy greater. Insulin and lipoprotein(a) levels were elevated as well. These results suggest that microtransferrinuria may be a signal of chronic complications of diabetes.

关 键 词：糖尿病 NIDDM 转铁蛋白尿 慢性并发症 

分 类 号：R587.204[医药卫生—内分泌]