前列腺素E_1联合氯沙坦降低早期糖尿病肾病蛋白尿的效果  

COMBINED THERAPY OF PGE_1 AND LOSARTAN FOR PROTEINURIA IN PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY

作　　者：孙建平[1] 滕静[1] 肖敬华[1] 董晖[1] 

机构地区：[1]青岛大学医学院附属医院肾内科,山东青岛266003

出　　处：《青岛大学医学院学报》2007年第6期503-504,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的观察前列腺素E1联合氯沙坦对早期糖尿病肾病蛋白尿的治疗效果。方法将入选的52例2型糖尿病肾病病人随机分为2组,对照组27例,每天给予氯沙坦100mg口服;治疗组25例,在对照组基础上加用前列腺素E120μg静脉滴注,每天1次,14d为1疗程,2周后重复,共治疗2个疗程。治疗前和治疗后分别检测尿微量清蛋白排出量、血肌酐、尿素氮、血糖等指标。结果治疗组治疗后尿微量清蛋白排泄量较治疗前显著下降(t=4.36,P<0.01),血肌酐、尿素氮、血糖等水平与治疗前比较差异均无显著性(P>0.05)。对照组各指标治疗后与治疗前比较,差异无显著性(P>0.05)。治疗后治疗组尿微量清蛋白排出量较对照组显著下降(t=4.86,P<0.01)。结论前列腺素E1联合氯沙坦治疗糖尿病肾病可以降低尿微量清蛋白排出率,而且对肾功能及血糖无不良影响。Objective To observe the effect of prostaglandin E1 （ PGE1 ） and Losartan on proteinuria in patients with early diabetic nephropathy （DN）. Methods Fifty-five patients with incipient DN were divided randomly into two groups： treatment group （n=25） and control group （n=27）. The control group was given 100 mg Losartan daily; the treatment group, 100 mg Losartan plus 20 μg PGEI daily. Two 14 day courses of treatment were separated by a two week interval. The relative indexes between the two groups were observed and compared. Results In the treatment group, 24 hours UAER was significantly reduced after treatment as compared with before treatment as well as with the control group 0=4.36 ,P〈0. 01）. Conclusion The prostaglandin E1 combined with Losartan may decrease proteinuria in patients with incipient diabetic nephropathy, which has no harmful effects on renal function and blood sugar.

关 键 词：前列腺素E类 氯沙坦 糖尿病肾病 白蛋白尿 

分 类 号：R587.2[医药卫生—内分泌]