多种尿蛋白联合检测诊断早期糖尿病肾病  

DETECTION OF DIFFERENT PROTEINURIA IN THE DIAGNOSIS OF INCIPIENT DIABETIC NEPHROPATHY

作　　者：武革[1] 刘付贞[1] 张炜贞[1] 秦光彩[1] 周伟正[1] 司徒洁[1] 

机构地区：[1]广东医学院附属医院,湛江524001

出　　处：《广东医学院学报》1997年第1期13-14,共2页Journal of Guangdong Medical College

摘　　要：目的：联合检测多种尿蛋白对早期糖尿病肾病的诊断价值。方法：用RIA法检测57例糖尿病患者（分为3组：Ⅰ组28例，为正常白蛋白尿组；Ⅱ组22例，为微量白蛋白尿组；Ⅲ组7例，为大量白蛋白尿组）的24h原蛋白、免疫球蛋白，β2微球蛋白、血肌酐、内生肌酐清除率，并进行比较研究。结果：微量白蛋白尿组原白蛋白与免疫球蛋白明显高于对照组（P＜0．01），尿β2微球蛋白与正常组差异无显著（P＞0．05），微量白蛋白尿组的血肌酐、内生肌酐清除率较对照组无显著升高（P＞0．05），但血β2微球蛋白较对照组升高（P＜0.05）。结论：尿白蛋白、免疫球蛋白升高是糖尿病肾病早期诊断的敏感指标，优于尿β2微球蛋白。血β2微球蛋白、血肌酐、内生肌酐清除率对糖尿病肾病无早期诊断价值。Objective: To find out which proteinuria plays role in the diagnosis of incipient diabetic nephropathy. Methods: Urinary albumin, immunoglobulin G (IgG), β2-microglobulin (β2-MG), and serum β2-MG,creatinine,endogenous creatinine clearance rate were measured in 57 patients with diabetes mellitus, who were allotted to three groups according to albumin quantity excreted in urine (group Ⅰ,normal　urine albumin group, n = 28, albumin< 12mg/24h urine; group Ⅱ, microalbuminuria group, n = 22, albumin 12~ 300mg/24h urine: and group Ⅲ,great quantity urine albumin group, n = 7,alburnin>300mg/24h urine). Results: Urinary albumin IgG, and serum β2-MG were significantly higer in group Ⅱ than in group Ⅰ (P<0. 001, P<0. 05), but no significant differences of urine β2-MG,serum creatinine, and endogenous creatinine rate between the two groups were found (P>0. 05), Conclusion: urinary albumin and IgG are more sensitivc indices in the diagnosis of incipient diabctic nephropathy compared with β2MG. Serum β2-MG,creatinine and endogenous creatinine clearance rate have not diagnostie value for early diabetic nephropathy.

关 键 词：糖尿病肾病 糖尿病 并发症 诊断 尿蛋白 

分 类 号：R587.204[医药卫生—内分泌]