阿拉伯半乳聚糖-5-氟脲嘧啶的合成与缓释性能  

Synthesis and Release Function of Arabinogalactan-5-fluorouracil

作　　者：马艳丽[1] 方桂珍[1] 金钟玲[1] 

机构地区：[1]东北林业大学材料工程与技术学院,黑龙江哈尔滨150040

出　　处：《林产化学与工业》2007年第B10期117-120,共4页Chemistry and Industry of Forest Products

基　　金：黑龙江省重点项目资助(GB05B601-02)

摘　　要：以兴安落叶松木材加工剩余物中提取的阿拉伯半乳聚糖(AG)为原料,与5-氟脲嘧啶合成了载药率为6.38%的阿拉伯半乳聚糖-5-氟脲嘧啶(AGF)。通过红外光谱和紫外光谱验证合成反应机理,并考察了AGF在pH值7.2的磷酸盐缓冲溶液中5-氟脲嘧啶的缓释性能,AGF缓释52 h后5-氟脲嘧啶的累积释放率为16.52%。Arabinogalactan, which was extracted from the processed wood residue of Larix gmelinii（ Rupr. ）, was reacted with 5-fluorouracil to obtain the novel arabinogalactan-5-fluouracil （ AGF）, which has a loaded capacity of 6.38 %. The mechanism of reaction was corroborated via infrared and ultraviolet spectrometries. Its delayed releasing function was characterized by the curve of cumulative release percentage in the phosphate buffer （ pH value 7.2 ） solution. The drug releasing rate was 16.52 % in 52 h.

关 键 词：兴安落叶松 阿拉伯半乳聚糖 5-脲嘧啶 缓释 

分 类 号：TQ351.014[化学工程]