DNA单链构象多态性原理初探  

Study on Principles of DNA Single Strand Conformation Polymorphism

作　　者：戚豫[1] 唐炬[1] 黄丽英[1] 

机构地区：[1]北京医科大学第一医院儿科

出　　处：《基础医学与临床》1997年第2期142-146,共5页Basic and Clinical Medicine

摘　　要：通过总结５年来的实验结果和１１０篇统计文献报道的结果，阐明了ＳＳＣＰ适用于能够引起ＤＮＡ单链中发夹结构改变的突变的检出，并据此提出ＳＳＣＰ实验原则。By analyses of our experimental results accumulated in the past 5 years as well as the reported results published in 1 1 0 papers , the following is pin-pointed , SSCP method is suitable to reveal the mutation which can change the hair-pin-loop structure of DNA single strand. Accordingly some principles for SSCP experiment have been prolosed.

关 键 词：单链构象多态性 发夹结构 DNA突变 检测方法 

分 类 号：Q346.5[生物学—遗传学] Q503