被动吸烟孕妇血中儿茶酚胺的含量及其与低体重新生儿发生率的关系  

Relationship between the Plasma Catecholamine Level in Gravidas and the Incidences of Low Birth Weight Infant Caused by Passive Smoking

作　　者：林邦和[1,2,3] 朱舜丽[1,2,3] 邵炳英 史珊珊 

机构地区：[1]安徽中医学院中西医结合临床医学系 [2]安徽中医学院针灸经络研究所生化研究室 [3]合肥市妇婴保健院

出　　处：《基础医学与临床》1997年第2期146-150,共5页Basic and Clinical Medicine

摘　　要：用荧光分光光度法测定了不同孕期的２７５例被动吸烟孕妇和１３０例正常妊娠妇女血中儿茶酚胺（ＣＡ）含量，并对其与低出生体重儿（ＬＢＷ）发生率之间的关系进行了探讨。结果表明：被动吸烟Ａ组（平均每日被动吸烟５～１４支）和Ｂ组（平均每日≥１５支）孕妇孕中期和孕早期血中去甲肾上腺素（ＮＥ）含量，均显著高于同孕期正常妊娠组（Ｐ＜０．０５），且Ｂ组孕中期含量升高尤为显著（Ｐ＜０．０１）；多巴胺（ＤＡ）含量与正常妊娠组比，仅Ｂ组临产前含量显著降低（Ｐ＜０．０５）；被动吸烟Ａ、８两组ＬＢＷ发生率分别是正常妊娠组的２．２７倍和３．２１倍，其中小于胎龄儿（ＳＧＡ）的发生率分别是正常妊娠组的２．９１和３．５０倍。提示被动吸烟所致孕妇血中ＮＥ明显升高与ＬＢＷ的发生可能有关系。因此，社会和家庭对孕妇被动吸烟可能给胎儿发育所带来的危害应给予足够的重视。By fluorescence spectrophotometry the contents of plasma catecholamines were meassured in 275 gravidas with passive smoking and 1 30 normal gravidas. It was found : ( 1 )the contents of NE in passive smoking groups A (5～14 cigarets/d)and B(≥1 5 cigarets/d)were obviously higher than the normal pregnant group separately from the 2nd and the 1 st trimester untill parturiency CP<0. 05 or P < 0. 01 ) ; ( 2 ) the contents of DA only in group B were markedly reduced before parturiency ( P < 0. 05 ) : ( 3 ) the incidences of low birth weight infant (LBW ) in groups A and B were separately 2 . 27 and 3. 2 1 times of that in the normal pregnant group . and the incidentces of SGA in LBW of group A and B were 2. 91 and 3. 50 times . These results indicate that passive smoking could increase contents of NE in gravidas , and the changes of the contents was strongly related to the incidences of LBW , especially of SGA.

关 键 词：吸烟污染 孕妇 婴儿 低出生体重儿 儿茶酚胺 

分 类 号：R163[医药卫生—公共卫生与预防医学] R714.431