骨及软组织损伤时白细胞介素1β与白细胞介素6变化及清热活血消肿合剂的干预效应(英文)  

Interventional effect of Qingre Huoxue Xiaozhong composition on interleukin 1 beta and interleukin 6 levels following bone and soft tissue injury

作　　者：薛长连[1] 吴力克[2] 刘立[3] 齐艳[1] 

机构地区：[1]解放军第四○一医院中医科,山东省青岛市266071 [2]解放军第四○一医院全军航海病医学专科中心实验室,山东省青岛市266071 [3]解放军第三○五医院中医科,北京市100017

出　　处：《中国组织工程研究与临床康复》2007年第41期8408-8410,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：海军医药卫生科研立项课题(ozhw13)~~

摘　　要：背景:作者自制的清热活血消肿Ⅰ,Ⅱ合剂治疗骨折并软组织损伤取得了良好疗效,但其机制尚不明确。目的:观察清热活血消肿合剂对闭合性骨伤所致软组织损伤患者血清白细胞介素1β、白细胞介素6的影响。设计:随机对照观察。单位:解放军第四○一医院中医科病房。对象:选择2000-02/2002-02在解放军第四○一医院中医科住院的骨折早、中期合并软组织损伤患者88例,均自愿参加观察。按随机数字表法分为2组,清热活血消肿Ⅰ+Ⅱ合剂组45例,清热活血消肿Ⅱ合剂组43例。清热活血消肿Ⅰ合剂为内服剂,Ⅱ合剂为外,洗剂。方法:①治疗骨伤:两组均给予钙尔奇D片及壮骨关节丸口服。②治疗软组织损伤:清热活血消肿Ⅰ+Ⅱ合剂组口服自制清热活血消肿Ⅰ合剂,每付药水煎450mL,分装成3袋,150mL/袋,3次/d;外用清热活血消肿Ⅱ合剂,洗患部,每付药水煎600mL,分装4袋,150mL/袋,每次取4袋药加水2000mL加热,洗患处,2次/d,每次,洗20～30min(4袋药可连续,洗2d)。清热活血消肿Ⅱ合剂组仅外用清热活血消肿Ⅱ合剂,洗患部,具体用法与清热活血消肿Ⅰ+Ⅱ合剂组相同。两组患者均以10d为1个疗程,共治疗2个疗程,分别于治疗前、1个疗程、2个疗程后应用酶联免疫吸附试剂盒检测患者血清白细胞介素1β、白细胞介素6含量并进行比较。主要观察指标:两组患者治疗前、治疗1,2个疗程后的血清白细胞介素1β、白细胞介素6含量。结果:清热活血消肿Ⅰ+Ⅱ合剂组治疗2个疗程后白细胞介素1β和白细胞介素6水平均较治疗前、治疗1个疗程后显著降低(P<0.05～0.01),亦较同时间点清热活血消肿Ⅱ合剂组显著降低(P<0.05)。此外,清热活血消肿Ⅰ+Ⅱ合剂组治疗1个疗程后白细胞介素1β和白细胞介素6水平亦较治疗前显著降低(P<0.05)。清热活血消肿Ⅱ合剂组治疗2个疗程后白细胞介素1β水平较治疗前显著降低(P<0.05),白�BACKGROUND： Qingre Huoxue Xiaozhong composition Ⅰ and Ⅱ made by ourselves are effective in treating bone fracture complicated by soft tissue injury. However, its mechanism is still unclear. OB3 E CTIVE： To observe the effect of Qingre Huoxue Xiaozhong composition on the levels of interleukin 1β（IL-1 β） and intedeukin 6（IL-6） in serum of patients with closed bone injury-induced soft tissue injury. DESIGN： Randomized controlled observation SETTING： Wards of the Department of Traditional Chinese Medicine, the 401 Hospital of Chinese PLA. PARTICIPANTS： Eighty-eight inpatients with bone fracture at early and moderate stages accompanied by soft tissue injury were chosen as volunteers to be studied in the Department of Traditional Chinese Medicine, the 401 Hospital of Chinese PLA between February 2000 and February 2002. The involved inpatients were assigned into 2 groups according to the table of random digit： Qingre Huoxue Xiaozhong composition Ⅰ ＋ Ⅱ group （n =45） and Qingre Huoxue Xiaozhong composition Ⅱ group （n =43）. Qingre Huoxue Xiaozhong composition Ⅰ was for internal administration, and Qingre Huoxue Xiaozhong composition Ⅱ was for external fumigation. METHODS ： （1） Treatment of bone injury： Both caltrate D pellets and pills for strengthening bone joints were used in two groups. （2） Treatment of soft tissue injury： In the Qingre Huoxue Xiaozhong composition Ⅰ ＋ Ⅱ group, Qingre Huoxue Xiaozhong composition Ⅰ was decocted. Each decoction was 450 mL, and was packed into 3 pouches, 150 mL/pouch, three times a day; Qingre Huoxue Xiaozhong composition Ⅱ was decocted. Each decoction was 600 mL, and was packed into 4 pouches, 150 mL/pouch. Four pouches of Qingre Huoxue Xiaozhong composition Ⅱ was diluted by 2 000 mL water, then heated and used for fume-washing, twice a day, 20 to 30 minutes once. Four pouches could be used for fume-washing for 2 days successively. In the Qingre Huoxue Xiaozhong composition Ⅱ group, only Qingre Huoxue Xiaozhong com

关 键 词：骨折/中医药疗法 软组织损伤/中医药疗法 细胞因子类 

分 类 号：R274.3[医药卫生—中医骨伤科学]